IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v15y2024i1d10.1038_s41467-024-45255-6.html
   My bibliography  Save this article

Tuning oxidant and antioxidant activities of ceria by anchoring copper single-site for antibacterial application

Author

Listed:
  • Peng Jiang

    (Tsinghua University)

  • Ludan Zhang

    (Peking University School and Hospital of Stomatology)

  • Xiaolong Liu

    (Laboratory of Theoretical and Computational Nanoscience, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Chinese Academy of Sciences)

  • Chenliang Ye

    (Tsinghua University)

  • Peng Zhu

    (Tsinghua University)

  • Ting Tan

    (Laboratory of Theoretical and Computational Nanoscience, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Chinese Academy of Sciences)

  • Dingsheng Wang

    (Tsinghua University)

  • Yuguang Wang

    (Peking University School and Hospital of Stomatology)

Abstract

The reaction system of hydrogen peroxide (H2O2) catalyzed by nanozyme has a broad prospect in antibacterial treatment. However, the complex catalytic activities of nanozymes lead to multiple pathways reacting in parallel, causing uncertain antibacterial results. New approach to effectively regulate the multiple catalytic activities of nanozyme is in urgent need. Herein, Cu single site is modified on nanoceria with various catalytic activities, such as peroxidase-like activity (POD) and hydroxyl radical antioxidant capacity (HORAC). Benefiting from the interaction between coordinated Cu and CeO2 substrate, POD is enhanced while HORAC is inhibited, which is further confirmed by density functional theory (DFT) calculations. Cu-CeO2 + H2O2 system shows good antibacterial properties both in vitro and in vivo. In this work, the strategy based on the interaction between coordinated metal and carrier provides a general clue for optimizing the complex activities of nanozymes.

Suggested Citation

  • Peng Jiang & Ludan Zhang & Xiaolong Liu & Chenliang Ye & Peng Zhu & Ting Tan & Dingsheng Wang & Yuguang Wang, 2024. "Tuning oxidant and antioxidant activities of ceria by anchoring copper single-site for antibacterial application," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-45255-6
    DOI: 10.1038/s41467-024-45255-6
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-024-45255-6
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-024-45255-6?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Hao-Xin Liu & Shan-Qing Li & Wei-Wei Wang & Wen-Zhu Yu & Wu-Jun Zhang & Chao Ma & Chun-Jiang Jia, 2022. "Partially sintered copper‒ceria as excellent catalyst for the high-temperature reverse water gas shift reaction," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    2. Feng Gao & Tianyi Shao & Yunpeng Yu & Yujie Xiong & Lihua Yang, 2021. "Surface-bound reactive oxygen species generating nanozymes for selective antibacterial action," Nature Communications, Nature, vol. 12(1), pages 1-18, December.
    3. Jinwei Xu & Xueli Zheng & Zhiping Feng & Zhiyi Lu & Zewen Zhang & William Huang & Yanbin Li & Djordje Vuckovic & Yuanqing Li & Sheng Dai & Guangxu Chen & Kecheng Wang & Hansen Wang & James K. Chen & W, 2021. "Organic wastewater treatment by a single-atom catalyst and electrolytically produced H2O2," Nature Sustainability, Nature, vol. 4(3), pages 233-241, March.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Xiaolong Gao & Huan Wei & Wenjie Ma & Wenjie Wu & Wenliang Ji & Junjie Mao & Ping Yu & Lanqun Mao, 2024. "Inflammation-free electrochemical in vivo sensing of dopamine with atomic-level engineered antioxidative single-atom catalyst," Nature Communications, Nature, vol. 15(1), pages 1-12, December.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Kaiyuan Wang & Qing Hong & Caixia Zhu & Yuan Xu & Wang Li & Ying Wang & Wenhao Chen & Xiang Gu & Xinghua Chen & Yanfeng Fang & Yanfei Shen & Songqin Liu & Yuanjian Zhang, 2024. "Metal-ligand dual-site single-atom nanozyme mimicking urate oxidase with high substrates specificity," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    2. Shujuan Liu & Teng Li & Feng Shi & Haiying Ma & Bin Wang & Xingchao Dai & Xinjiang Cui, 2023. "Constructing multiple active sites in iron oxide catalysts for improving carbonylation reactions," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    3. Qi Huang & Baokai Xia & Ming Li & Hongxin Guan & Markus Antonietti & Sheng Chen, 2024. "Single-zinc vacancy unlocks high-rate H2O2 electrosynthesis from mixed dioxygen beyond Le Chatelier principle," Nature Communications, Nature, vol. 15(1), pages 1-10, December.
    4. Hao Meng & Yusen Yang & Tianyao Shen & Zhiming Yin & Lei Wang & Wei Liu & Pan Yin & Zhen Ren & Lirong Zheng & Jian Zhang & Feng-Shou Xiao & Min Wei, 2023. "Designing Cu0−Cu+ dual sites for improved C−H bond fracture towards methanol steam reforming," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    5. Chaoran Dong & Yilong Yang & Xuemin Hu & Yoonjun Cho & Gyuyong Jang & Yanhui Ao & Luyang Wang & Jinyou Shen & Jong Hyeok Park & Kan Zhang, 2022. "Self-cycled photo-Fenton-like system based on an artificial leaf with a solar-to-H2O2 conversion efficiency of 1.46%," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    6. Tao Liu & Shuang Chai & Mingyang Li & Xu Chen & Yutao Xie & Zehui Zhao & Jingjing Xie & Yunpeng Yu & Feng Gao & Feng Zhu & Lihua Yang, 2024. "A nanoparticle-based sonodynamic therapy reduces Helicobacter pylori infection in mouse without disrupting gut microbiota," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    7. Shuo Zhang & Jianghua Wu & Mengting Zheng & Xin Jin & Zihan Shen & Zhonghua Li & Yanjun Wang & Quan Wang & Xuebin Wang & Hui Wei & Jiangwei Zhang & Peng Wang & Shanqing Zhang & Liyan Yu & Lifeng Dong , 2023. "Fe/Cu diatomic catalysts for electrochemical nitrate reduction to ammonia," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    8. Zhenzhen Liu & Helong Li & Xueying Gao & Xuan Guo & Shuizhong Wang & Yunming Fang & Guoyong Song, 2022. "Rational highly dispersed ruthenium for reductive catalytic fractionation of lignocellulose," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    9. Haibin Si & Dexin Du & Chengcheng Jiao & Yan Sun & Lu Li & Bo Tang, 2024. "Biomimetic synergistic effect of redox site and Lewis acid for construction of efficient artificial enzyme," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    10. Yongyang Song & Jiajia Zhou & Zhongpeng Zhu & Xiaoxia Li & Yue Zhang & Xinyi Shen & Padraic O’Reilly & Xiuling Li & Xinmiao Liang & Lei Jiang & Shutao Wang, 2023. "Heterostructure particles enable omnidispersible in water and oil towards organic dye recycle," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    11. Liangbo Xie & Pengfei Wang & Yi Li & Dongpeng Zhang & Denghui Shang & Wenwen Zheng & Yuguo Xia & Sihui Zhan & Wenping Hu, 2022. "Pauling-type adsorption of O2 induced electrocatalytic singlet oxygen production on N–CuO for organic pollutants degradation," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    12. Lei Zhang & Hanwen Liu & Bo Song & Jialun Gu & Lanxi Li & Wenhui Shi & Gan Li & Shiyu Zhong & Hui Liu & Xiaobo Wang & Junxiang Fan & Zhi Zhang & Pengfei Wang & Yonggang Yao & Yusheng Shi & Jian Lu, 2024. "Wood-inspired metamaterial catalyst for robust and high-throughput water purification," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    13. Zhuangzhuang Qiao & Kai Zhang & Jin Liu & Daojian Cheng & Bingran Yu & Nana Zhao & Fu-Jian Xu, 2022. "Biomimetic electrodynamic nanoparticles comprising ginger-derived extracellular vesicles for synergistic anti-infective therapy," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    14. Qi, Xingang & Ren, Zhenhua & Meng, Fanrui & Lu, Libo & Liu, Fan & Li, Xunjun & Jin, Hui & Chen, Yunan & Guo, Liejin, 2024. "Thermodynamic and environmental analysis of an integrated multi-effect evaporation and organic wastewater supercritical water gasification system for hydrogen production," Applied Energy, Elsevier, vol. 357(C).
    15. Xiao Zhou & Yuan Min & Changming Zhao & Cai Chen & Ming-Kun Ke & Shi-Lin Xu & Jie-Jie Chen & Yuen Wu & Han-Qing Yu, 2024. "Constructing sulfur and oxygen super-coordinated main-group electrocatalysts for selective and cumulative H2O2 production," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    16. Xu Zhang & Hui Su & Peixin Cui & Yongyong Cao & Zhenyuan Teng & Qitao Zhang & Yang Wang & Yibo Feng & Ran Feng & Jixiang Hou & Xiyuan Zhou & Peijie Ma & Hanwen Hu & Kaiwen Wang & Cong Wang & Liyong Ga, 2023. "Developing Ni single-atom sites in carbon nitride for efficient photocatalytic H2O2 production," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-45255-6. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.