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Surface-bound reactive oxygen species generating nanozymes for selective antibacterial action

Author

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  • Feng Gao

    (Hefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China
    CAS Key Laboratory of Soft Matter Chemistry, University of Science and Technology of China
    School of Chemistry and Materials Science, University of Science and Technology of China)

  • Tianyi Shao

    (Hefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China
    School of Chemistry and Materials Science, University of Science and Technology of China)

  • Yunpeng Yu

    (Hefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China
    CAS Key Laboratory of Soft Matter Chemistry, University of Science and Technology of China
    School of Chemistry and Materials Science, University of Science and Technology of China)

  • Yujie Xiong

    (Hefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China
    School of Chemistry and Materials Science, University of Science and Technology of China)

  • Lihua Yang

    (Hefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China
    CAS Key Laboratory of Soft Matter Chemistry, University of Science and Technology of China
    School of Chemistry and Materials Science, University of Science and Technology of China)

Abstract

Acting by producing reactive oxygen species (ROS) in situ, nanozymes are promising as antimicrobials. ROS’ intrinsic inability to distinguish bacteria from mammalian cells, however, deprives nanozymes of the selectivity necessary for an ideal antimicrobial. Here we report that nanozymes that generate surface-bound ROS selectively kill bacteria over mammalian cells. This result is robust across three distinct nanozymes that universally generate surface-bound ROS, with an oxidase-like silver-palladium bimetallic alloy nanocage, AgPd0.38, being the lead model. The selectivity is attributable to both the surface-bound nature of ROS these nanozymes generate and an unexpected antidote role of endocytosis. Though surface-bound, the ROS on AgPd0.38 efficiently eliminated antibiotic-resistant bacteria and effectively delayed the onset of bacterial resistance emergence. When used as coating additives, AgPd0.38 enabled an inert substrate to inhibit biofilm formation and suppress infection-related immune responses in mouse models. This work opens an avenue toward biocompatible nanozymes and may have implication in our fight against antimicrobial resistance.

Suggested Citation

  • Feng Gao & Tianyi Shao & Yunpeng Yu & Yujie Xiong & Lihua Yang, 2021. "Surface-bound reactive oxygen species generating nanozymes for selective antibacterial action," Nature Communications, Nature, vol. 12(1), pages 1-18, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-20965-3
    DOI: 10.1038/s41467-021-20965-3
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    Cited by:

    1. Kaiyuan Wang & Qing Hong & Caixia Zhu & Yuan Xu & Wang Li & Ying Wang & Wenhao Chen & Xiang Gu & Xinghua Chen & Yanfeng Fang & Yanfei Shen & Songqin Liu & Yuanjian Zhang, 2024. "Metal-ligand dual-site single-atom nanozyme mimicking urate oxidase with high substrates specificity," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    2. Tao Liu & Shuang Chai & Mingyang Li & Xu Chen & Yutao Xie & Zehui Zhao & Jingjing Xie & Yunpeng Yu & Feng Gao & Feng Zhu & Lihua Yang, 2024. "A nanoparticle-based sonodynamic therapy reduces Helicobacter pylori infection in mouse without disrupting gut microbiota," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    3. Peng Jiang & Ludan Zhang & Xiaolong Liu & Chenliang Ye & Peng Zhu & Ting Tan & Dingsheng Wang & Yuguang Wang, 2024. "Tuning oxidant and antioxidant activities of ceria by anchoring copper single-site for antibacterial application," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    4. Zhuangzhuang Qiao & Kai Zhang & Jin Liu & Daojian Cheng & Bingran Yu & Nana Zhao & Fu-Jian Xu, 2022. "Biomimetic electrodynamic nanoparticles comprising ginger-derived extracellular vesicles for synergistic anti-infective therapy," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    5. Haibin Si & Dexin Du & Chengcheng Jiao & Yan Sun & Lu Li & Bo Tang, 2024. "Biomimetic synergistic effect of redox site and Lewis acid for construction of efficient artificial enzyme," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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