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A nanoparticle-based sonodynamic therapy reduces Helicobacter pylori infection in mouse without disrupting gut microbiota

Author

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  • Tao Liu

    (University of Science and Technology of China
    University of Science and Technology of China
    University of Science and Technology of China)

  • Shuang Chai

    (University of Science and Technology of China
    University of Science and Technology of China
    University of Science and Technology of China)

  • Mingyang Li

    (University of Science and Technology of China
    University of Science and Technology of China
    University of Science and Technology of China)

  • Xu Chen

    (University of Science and Technology of China
    University of Science and Technology of China
    University of Science and Technology of China)

  • Yutao Xie

    (University of Science and Technology of China
    University of Science and Technology of China
    University of Science and Technology of China)

  • Zehui Zhao

    (University of Science and Technology of China
    University of Science and Technology of China
    University of Science and Technology of China)

  • Jingjing Xie

    (University of Science and Technology of China
    University of Science and Technology of China
    University of Science and Technology of China)

  • Yunpeng Yu

    (University of Science and Technology of China
    University of Science and Technology of China
    University of Science and Technology of China)

  • Feng Gao

    (University of Science and Technology of China)

  • Feng Zhu

    (University of Science and Technology of China)

  • Lihua Yang

    (University of Science and Technology of China
    University of Science and Technology of China
    University of Science and Technology of China)

Abstract

Infection by Helicobacter pylori, a prevalent global pathogen, currently requires antibiotic-based treatments, which often lead to antimicrobial resistance and gut microbiota dysbiosis. Here, we develop a non-antibiotic approach using sonodynamic therapy mediated by a lecithin bilayer-coated poly(lactic-co-glycolic) nanoparticle preloaded with verteporfin, Ver-PLGA@Lecithin, in conjunction with localized ultrasound exposure of a dosage permissible for ultrasound medical devices. This study reveals dual functionality of Ver-PLGA@Lecithin. It effectively neutralizes vacuolating cytotoxin A, a key virulence factor secreted by H. pylori, even in the absence of ultrasound. When coupled with ultrasound exposure, it inactivates H. pylori by generating reactive oxygen species, offering a potential solution to overcome antimicrobial resistance. In female mouse models bearing H. pylori infection, this sonodynamic therapy performs comparably to the standard triple therapy in reducing gastric infection. Significantly, unlike the antibiotic treatments, the sonodynamic therapy does not negatively disrupt gut microbiota, with the only major impact being upregulation of Lactobacillus, which is a bacterium widely used in yogurt products and probiotics. This study presents a promising alternative to the current antibiotic-based therapies for H. pylori infection, offering a reduced risk of antimicrobial resistance and minimal disturbance to the gut microbiota.

Suggested Citation

  • Tao Liu & Shuang Chai & Mingyang Li & Xu Chen & Yutao Xie & Zehui Zhao & Jingjing Xie & Yunpeng Yu & Feng Gao & Feng Zhu & Lihua Yang, 2024. "A nanoparticle-based sonodynamic therapy reduces Helicobacter pylori infection in mouse without disrupting gut microbiota," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
  • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-45156-8
    DOI: 10.1038/s41467-024-45156-8
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    References listed on IDEAS

    as
    1. Feng Gao & Tianyi Shao & Yunpeng Yu & Yujie Xiong & Lihua Yang, 2021. "Surface-bound reactive oxygen species generating nanozymes for selective antibacterial action," Nature Communications, Nature, vol. 12(1), pages 1-18, December.
    2. Yige Wu & Nadezhda V. Terekhanova & Wagma Caravan & Nataly Naser Al Deen & Preet Lal & Siqi Chen & Chia-Kuei Mo & Song Cao & Yize Li & Alla Karpova & Ruiyang Liu & Yanyan Zhao & Andrew Shinkle & Ilya , 2023. "Author Correction: Epigenetic and transcriptomic characterization reveals progression markers and essential pathways in clear cell renal cell carcinoma," Nature Communications, Nature, vol. 14(1), pages 1-1, December.
    3. Yige Wu & Nadezhda V. Terekhanova & Wagma Caravan & Nataly Naser Al Deen & Preet Lal & Siqi Chen & Chia-Kuei Mo & Song Cao & Yize Li & Alla Karpova & Ruiyang Liu & Yanyan Zhao & Andrew Shinkle & Ilya , 2023. "Epigenetic and transcriptomic characterization reveals progression markers and essential pathways in clear cell renal cell carcinoma," Nature Communications, Nature, vol. 14(1), pages 1-25, December.
    4. Qi Song & Ye Yang & Dongxian Jiang & Zhaoyu Qin & Chen Xu & Haixing Wang & Jie Huang & Lingli Chen & Rongkui Luo & Xiaolei Zhang & Yufeng Huang & Lei Xu & Zixiang Yu & Subei Tan & Minying Deng & Ruqun, 2022. "Proteomic analysis reveals key differences between squamous cell carcinomas and adenocarcinomas across multiple tissues," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
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