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Biomimetic electrodynamic nanoparticles comprising ginger-derived extracellular vesicles for synergistic anti-infective therapy

Author

Listed:
  • Zhuangzhuang Qiao

    (Beijing University of Chemical Technology
    Key Laboratory of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology), Ministry of Education
    Beijing University of Chemical Technology)

  • Kai Zhang

    (Beijing University of Chemical Technology
    Key Laboratory of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology), Ministry of Education
    Beijing University of Chemical Technology)

  • Jin Liu

    (Beijing University of Chemical Technology)

  • Daojian Cheng

    (Beijing University of Chemical Technology)

  • Bingran Yu

    (Beijing University of Chemical Technology
    Key Laboratory of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology), Ministry of Education
    Beijing University of Chemical Technology)

  • Nana Zhao

    (Beijing University of Chemical Technology
    Key Laboratory of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology), Ministry of Education
    Beijing University of Chemical Technology)

  • Fu-Jian Xu

    (Beijing University of Chemical Technology
    Key Laboratory of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology), Ministry of Education
    Beijing University of Chemical Technology)

Abstract

Nanotechnology enlightens promising antibacterial strategies while the complex in vivo infection environment poses a great challenge to the rational design of nanoplatforms for safe and effective anti-infective therapy. Herein, a biomimetic nanoplatform (EV-Pd-Pt) integrating electrodynamic Pd-Pt nanosheets and natural ginger-derived extracellular vesicles (EVs) is proposed. The introduction of ginger-derived EVs greatly endows EV-Pd-Pt with prolonged blood circulation without immune clearance, as well as accumulation at infection sites. More interestingly, EV-Pd-Pt can enter the interior of bacteria in an EV lipid-dependent manner. At the same time, reactive oxygen species are sustainably generated in situ to overcome the limitations of their short lifetime and diffusion distance. Notably, EV-Pd-Pt nanoparticle-mediated electrodynamic and photothermal therapy exhibit synergistic effects. Furthermore, the desirable biocompatibility and biosafety of the proposed nanoplatform guarantee the feasibility of in vivo applications. This proof-of-concept work holds significant promise for developing biomimetic nanoparticles by exploiting their intrinsic properties for synergistic anti-infective therapy.

Suggested Citation

  • Zhuangzhuang Qiao & Kai Zhang & Jin Liu & Daojian Cheng & Bingran Yu & Nana Zhao & Fu-Jian Xu, 2022. "Biomimetic electrodynamic nanoparticles comprising ginger-derived extracellular vesicles for synergistic anti-infective therapy," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
  • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-34883-5
    DOI: 10.1038/s41467-022-34883-5
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    References listed on IDEAS

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    Cited by:

    1. Zehui Wang & Anhua Wu & Wen Cheng & Yuhe Li & Dingxuan Li & Lai Wang & Xinfu Zhang & Yi Xiao, 2023. "Adoptive macrophage directed photodynamic therapy of multidrug-resistant bacterial infection," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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