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A controlled-release microchip

Author

Listed:
  • John T. Santini

    (Massachusetts Institute of Technology)

  • Michael J. Cima

    (Massachusetts Institute of Technology)

  • Robert Langer

    (Massachusetts Institute of Technology)

Abstract

Much previous work in methods of achieving complex drug-release patterns has focused on pulsatile release from polymeric materials in response to specific stimuli1, such as electric2,3,4,5 or magnetic6,7 fields, exposure to ultrasound7,8, light9 or enzymes10, and changes in pH11 or temperature12,13,14. An alternative method for achieving pulsatile release involves using microfabrication technology to develop active devices that incorporate micrometre-scale pumps, valves and flow channels to deliver liquid solutions15,16. Here we report a solid-state silicon microchip that can provide controlled release of single or multiple chemical substances on demand. The release mechanism is based on the electrochemical dissolution of thin anode membranes covering microreservoirs filled with chemicals in solid, liquid or gel form. We have conducted proof-of-principle release studies with a prototype microchip using gold and saline solution as a model electrode material and release medium, and we have demonstrated controlled, pulsatile release of chemical substances with this device.

Suggested Citation

  • John T. Santini & Michael J. Cima & Robert Langer, 1999. "A controlled-release microchip," Nature, Nature, vol. 397(6717), pages 335-338, January.
    • Handle: RePEc:nat:nature:v:397:y:1999:i:6717:d:10.1038_16898
    DOI: 10.1038/16898
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    Cited by:

    1. Yihang Wang & Zeka Chen & Brayden Davis & Will Lipman & Sicheng Xing & Lin Zhang & Tian Wang & Priyash Hafiz & Wanrong Xie & Zijie Yan & Zhili Huang & Juan Song & Wubin Bai, 2024. "Digital automation of transdermal drug delivery with high spatiotemporal resolution," Nature Communications, Nature, vol. 15(1), pages 1-18, December.

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