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Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries

Author

Listed:
  • Mary F Feitosa
  • Aldi T Kraja
  • Daniel I Chasman
  • Yun J Sung
  • Thomas W Winkler
  • Ioanna Ntalla
  • Xiuqing Guo
  • Nora Franceschini
  • Ching-Yu Cheng
  • Xueling Sim
  • Dina Vojinovic
  • Jonathan Marten
  • Solomon K Musani
  • Changwei Li
  • Amy R Bentley
  • Michael R Brown
  • Karen Schwander
  • Melissa A Richard
  • Raymond Noordam
  • Hugues Aschard
  • Traci M Bartz
  • Lawrence F Bielak
  • Rajkumar Dorajoo
  • Virginia Fisher
  • Fernando P Hartwig
  • Andrea R V R Horimoto
  • Kurt K Lohman
  • Alisa K Manning
  • Tuomo Rankinen
  • Albert V Smith
  • Salman M Tajuddin
  • Mary K Wojczynski
  • Maris Alver
  • Mathilde Boissel
  • Qiuyin Cai
  • Archie Campbell
  • Jin Fang Chai
  • Xu Chen
  • Jasmin Divers
  • Chuan Gao
  • Anuj Goel
  • Yanick Hagemeijer
  • Sarah E Harris
  • Meian He
  • Fang-Chi Hsu
  • Anne U Jackson
  • Mika Kähönen
  • Anuradhani Kasturiratne
  • Pirjo Komulainen
  • Brigitte Kühnel
  • Federica Laguzzi
  • Jian'an Luan
  • Nana Matoba
  • Ilja M Nolte
  • Sandosh Padmanabhan
  • Muhammad Riaz
  • Rico Rueedi
  • Antonietta Robino
  • M Abdullah Said
  • Robert A Scott
  • Tamar Sofer
  • Alena Stančáková
  • Fumihiko Takeuchi
  • Bamidele O Tayo
  • Peter J van der Most
  • Tibor V Varga
  • Veronique Vitart
  • Yajuan Wang
  • Erin B Ware
  • Helen R Warren
  • Stefan Weiss
  • Wanqing Wen
  • Lisa R Yanek
  • Weihua Zhang
  • Jing Hua Zhao
  • Saima Afaq
  • Najaf Amin
  • Marzyeh Amini
  • Dan E Arking
  • Tin Aung
  • Eric Boerwinkle
  • Ingrid Borecki
  • Ulrich Broeckel
  • Morris Brown
  • Marco Brumat
  • Gregory L Burke
  • Mickaël Canouil
  • Aravinda Chakravarti
  • Sabanayagam Charumathi
  • Yii-Der Ida Chen
  • John M Connell
  • Adolfo Correa
  • Lisa de las Fuentes
  • Renée de Mutsert
  • H Janaka de Silva
  • Xuan Deng
  • Jingzhong Ding
  • Qing Duan
  • Charles B Eaton
  • Georg Ehret
  • Ruben N Eppinga
  • Evangelos Evangelou
  • Jessica D Faul
  • Stephan B Felix
  • Nita G Forouhi
  • Terrence Forrester
  • Oscar H Franco
  • Yechiel Friedlander
  • Ilaria Gandin
  • He Gao
  • Mohsen Ghanbari
  • Bruna Gigante
  • C Charles Gu
  • Dongfeng Gu
  • Saskia P Hagenaars
  • Göran Hallmans
  • Tamara B Harris
  • Jiang He
  • Sami Heikkinen
  • Chew-Kiat Heng
  • Makoto Hirata
  • Barbara V Howard
  • M Arfan Ikram
  • InterAct Consortium
  • Ulrich John
  • Tomohiro Katsuya
  • Chiea Chuen Khor
  • Tuomas O Kilpeläinen
  • Woon-Puay Koh
  • José E Krieger
  • Stephen B Kritchevsky
  • Michiaki Kubo
  • Johanna Kuusisto
  • Timo A Lakka
  • Carl D Langefeld
  • Claudia Langenberg
  • Lenore J Launer
  • Benjamin Lehne
  • Cora E Lewis
  • Yize Li
  • Shiow Lin
  • Jianjun Liu
  • Jingmin Liu
  • Marie Loh
  • Tin Louie
  • Reedik Mägi
  • Colin A McKenzie
  • Thomas Meitinger
  • Andres Metspalu
  • Yuri Milaneschi
  • Lili Milani
  • Karen L Mohlke
  • Yukihide Momozawa
  • Mike A Nalls
  • Christopher P Nelson
  • Nona Sotoodehnia
  • Jill M Norris
  • Jeff R O'Connell
  • Nicholette D Palmer
  • Thomas Perls
  • Nancy L Pedersen
  • Annette Peters
  • Patricia A Peyser
  • Neil Poulter
  • Leslie J Raffel
  • Olli T Raitakari
  • Kathryn Roll
  • Lynda M Rose
  • Frits R Rosendaal
  • Jerome I Rotter
  • Carsten O Schmidt
  • Pamela J Schreiner
  • Nicole Schupf
  • William R Scott
  • Peter S Sever
  • Yuan Shi
  • Stephen Sidney
  • Mario Sims
  • Colleen M Sitlani
  • Jennifer A Smith
  • Harold Snieder
  • John M Starr
  • Konstantin Strauch
  • Heather M Stringham
  • Nicholas Y Q Tan
  • Hua Tang
  • Kent D Taylor
  • Yik Ying Teo
  • Yih Chung Tham
  • Stephen T Turner
  • André G Uitterlinden
  • Peter Vollenweider
  • Melanie Waldenberger
  • Lihua Wang
  • Ya Xing Wang
  • Wen Bin Wei
  • Christine Williams
  • Jie Yao
  • Caizheng Yu
  • Jian-Min Yuan
  • Wei Zhao
  • Alan B Zonderman
  • Diane M Becker
  • Michael Boehnke
  • Donald W Bowden
  • John C Chambers
  • Ian J Deary
  • Tõnu Esko
  • Martin Farrall
  • Paul W Franks
  • Barry I Freedman
  • Philippe Froguel
  • Paolo Gasparini
  • Christian Gieger
  • Jost Bruno Jonas
  • Yoichiro Kamatani
  • Norihiro Kato
  • Jaspal S Kooner
  • Zoltán Kutalik
  • Markku Laakso
  • Cathy C Laurie
  • Karin Leander
  • Terho Lehtimäki
  • Lifelines Cohort Study
  • Patrik K E Magnusson
  • Albertine J Oldehinkel
  • Brenda W J H Penninx
  • Ozren Polasek
  • David J Porteous
  • Rainer Rauramaa
  • Nilesh J Samani
  • James Scott
  • Xiao-Ou Shu
  • Pim van der Harst
  • Lynne E Wagenknecht
  • Nicholas J Wareham
  • Hugh Watkins
  • David R Weir
  • Ananda R Wickremasinghe
  • Tangchun Wu
  • Wei Zheng
  • Claude Bouchard
  • Kaare Christensen
  • Michele K Evans
  • Vilmundur Gudnason
  • Bernardo L Horta
  • Sharon L R Kardia
  • Yongmei Liu
  • Alexandre C Pereira
  • Bruce M Psaty
  • Paul M Ridker
  • Rob M van Dam
  • W James Gauderman
  • Xiaofeng Zhu
  • Dennis O Mook-Kanamori
  • Myriam Fornage
  • Charles N Rotimi
  • L Adrienne Cupples
  • Tanika N Kelly
  • Ervin R Fox
  • Caroline Hayward
  • Cornelia M van Duijn
  • E Shyong Tai
  • Tien Yin Wong
  • Charles Kooperberg
  • Walter Palmas
  • Kenneth Rice
  • Alanna C Morrison
  • Paul Elliott
  • Mark J Caulfield
  • Patricia B Munroe
  • Dabeeru C Rao
  • Michael A Province
  • Daniel Levy

Abstract

Heavy alcohol consumption is an established risk factor for hypertension; the mechanism by which alcohol consumption impact blood pressure (BP) regulation remains unknown. We hypothesized that a genome-wide association study accounting for gene-alcohol consumption interaction for BP might identify additional BP loci and contribute to the understanding of alcohol-related BP regulation. We conducted a large two-stage investigation incorporating joint testing of main genetic effects and single nucleotide variant (SNV)-alcohol consumption interactions. In Stage 1, genome-wide discovery meta-analyses in ≈131K individuals across several ancestry groups yielded 3,514 SNVs (245 loci) with suggestive evidence of association (P

Suggested Citation

  • Mary F Feitosa & Aldi T Kraja & Daniel I Chasman & Yun J Sung & Thomas W Winkler & Ioanna Ntalla & Xiuqing Guo & Nora Franceschini & Ching-Yu Cheng & Xueling Sim & Dina Vojinovic & Jonathan Marten & S, 2018. "Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries," PLOS ONE, Public Library of Science, vol. 13(6), pages 1-36, June.
  • Handle: RePEc:plo:pone00:0198166
    DOI: 10.1371/journal.pone.0198166
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    References listed on IDEAS

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    1. Surina Singh & Ananyo Choudhury & Scott Hazelhurst & Nigel J. Crowther & Palwendé R. Boua & Hermann Sorgho & Godfred Agongo & Engelbert A. Nonterah & Lisa K. Micklesfield & Shane A. Norris & Isaac Kis, 2023. "Genome-wide association study meta-analysis of blood pressure traits and hypertension in sub-Saharan African populations: an AWI-Gen study," Nature Communications, Nature, vol. 14(1), pages 1-14, December.

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