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Integrative genome-wide analyses identify novel loci associated with kidney stones and provide insights into its genetic architecture

Author

Listed:
  • Xingjie Hao

    (Huazhong University of Science and Technology)

  • Zhonghe Shao

    (Huazhong University of Science and Technology)

  • Ning Zhang

    (Huazhong University of Science and Technology)

  • Minghui Jiang

    (Huazhong University of Science and Technology)

  • Xi Cao

    (Huazhong University of Science and Technology)

  • Si Li

    (Huazhong University of Science and Technology)

  • Yunlong Guan

    (Huazhong University of Science and Technology)

  • Chaolong Wang

    (Huazhong University of Science and Technology)

Abstract

Kidney stone disease (KSD) is a complex disorder with high heritability and prevalence. We performed a large genome-wide association study (GWAS) meta-analysis for KSD to date, including 720,199 individuals with 17,969 cases in European population. We identified 44 susceptibility loci, including 28 novel loci. Cell type-specific analysis pinpointed the proximal tubule as the most relevant cells where susceptibility variants might act through a tissue-specific fashion. By integrating kidney-specific omics data, we prioritized 223 genes which strengthened the importance of ion homeostasis, including calcium and magnesium in stone formation, and suggested potential target drugs for the treatment. The genitourinary and digestive diseases showed stronger genetic correlations with KSD. In this study, we generate an atlas of candidate genes, tissue and cell types involved in the formation of KSD. In addition, we provide potential drug targets for KSD treatment and insights into shared regulation with other diseases.

Suggested Citation

  • Xingjie Hao & Zhonghe Shao & Ning Zhang & Minghui Jiang & Xi Cao & Si Li & Yunlong Guan & Chaolong Wang, 2023. "Integrative genome-wide analyses identify novel loci associated with kidney stones and provide insights into its genetic architecture," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-43400-1
    DOI: 10.1038/s41467-023-43400-1
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