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A multi-ethnic polygenic risk score is associated with hypertension prevalence and progression throughout adulthood

Author

Listed:
  • Nuzulul Kurniansyah

    (Brigham and Women’s Hospital)

  • Matthew O. Goodman

    (Brigham and Women’s Hospital
    Harvard Medical School)

  • Tanika N. Kelly

    (Tulane University School of Public Health and Tropical Medicine)

  • Tali Elfassy

    (University of Miami Miller School of Medicine)

  • Kerri L. Wiggins

    (University of Washington)

  • Joshua C. Bis

    (University of Washington)

  • Xiuqing Guo

    (The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center)

  • Walter Palmas

    (Columbia University Medical Center)

  • Kent D. Taylor

    (The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center)

  • Henry J. Lin

    (The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center)

  • Jeffrey Haessler

    (Fred Hutchinson Cancer Center)

  • Yan Gao

    (University of Mississippi Medical Center)

  • Daichi Shimbo

    (Columbia University Irving Medical Center)

  • Jennifer A. Smith

    (University of Michigan School of Public Health)

  • Bing Yu

    (University of Texas Health Science Center at Houston)

  • Elena V. Feofanova

    (University of Texas Health Science Center at Houston)

  • Roelof A. J. Smit

    (Icahn School of Medicine at Mount Sinai)

  • Zhe Wang

    (Icahn School of Medicine at Mount Sinai)

  • Shih-Jen Hwang

    (Boston University)

  • Simin Liu

    (Brown University)

  • Sylvia Wassertheil-Smoller

    (Albert Einstein College of Medicine)

  • JoAnn E. Manson

    (Harvard Medical School
    Harvard T.H. Chan School of Public Health)

  • Donald M. Lloyd-Jones

    (Northwestern University)

  • Stephen S. Rich

    (University of Virginia School of Medicine)

  • Ruth J. F. Loos

    (Icahn School of Medicine at Mount Sinai)

  • Susan Redline

    (Brigham and Women’s Hospital
    Harvard Medical School)

  • Adolfo Correa

    (University of Mississippi Medical Center)

  • Charles Kooperberg

    (Fred Hutchinson Cancer Center)

  • Myriam Fornage

    (University of Texas Health Science Center at Houston
    University of Texas Health Science Center at Houston)

  • Robert C. Kaplan

    (Fred Hutchinson Cancer Center
    Albert Einstein College of Medicine)

  • Bruce M. Psaty

    (University of Washington)

  • Jerome I. Rotter

    (The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center)

  • Donna K. Arnett

    (University of Kentucky)

  • Alanna C. Morrison

    (University of Texas Health Science Center at Houston)

  • Nora Franceschini

    (University of North Carolina)

  • Daniel Levy

    (Lung and Blood Institute
    The Framingham Heart Study)

  • Tamar Sofer

    (Brigham and Women’s Hospital
    Harvard Medical School
    Harvard T.H. Chan School of Public Health)

Abstract

In a multi-stage analysis of 52,436 individuals aged 17-90 across diverse cohorts and biobanks, we train, test, and evaluate a polygenic risk score (PRS) for hypertension risk and progression. The PRS is trained using genome-wide association studies (GWAS) for systolic, diastolic blood pressure, and hypertension, respectively. For each trait, PRS is selected by optimizing the coefficient of variation (CV) across estimated effect sizes from multiple potential PRS using the same GWAS, after which the 3 trait-specific PRSs are combined via an unweighted sum called “PRSsum”, forming the HTN-PRS. The HTN-PRS is associated with both prevalent and incident hypertension at 4-6 years of follow up. This association is further confirmed in age-stratified analysis. In an independent biobank of 40,201 individuals, the HTN-PRS is confirmed to be predictive of increased risk for coronary artery disease, ischemic stroke, type 2 diabetes, and chronic kidney disease.

Suggested Citation

  • Nuzulul Kurniansyah & Matthew O. Goodman & Tanika N. Kelly & Tali Elfassy & Kerri L. Wiggins & Joshua C. Bis & Xiuqing Guo & Walter Palmas & Kent D. Taylor & Henry J. Lin & Jeffrey Haessler & Yan Gao , 2022. "A multi-ethnic polygenic risk score is associated with hypertension prevalence and progression throughout adulthood," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-31080-2
    DOI: 10.1038/s41467-022-31080-2
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    References listed on IDEAS

    as
    1. Robert M. Maier & Zhihong Zhu & Sang Hong Lee & Maciej Trzaskowski & Douglas M. Ruderfer & Eli A. Stahl & Stephan Ripke & Naomi R. Wray & Jian Yang & Peter M. Visscher & Matthew R. Robinson, 2018. "Improving genetic prediction by leveraging genetic correlations among human diseases and traits," Nature Communications, Nature, vol. 9(1), pages 1-17, December.
    2. L. Duncan & H. Shen & B. Gelaye & J. Meijsen & K. Ressler & M. Feldman & R. Peterson & B. Domingue, 2019. "Analysis of polygenic risk score usage and performance in diverse human populations," Nature Communications, Nature, vol. 10(1), pages 1-9, December.
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    Cited by:

    1. Nuzulul Kurniansyah & Matthew O. Goodman & Alyna T. Khan & Jiongming Wang & Elena Feofanova & Joshua C. Bis & Kerri L. Wiggins & Jennifer E. Huffman & Tanika Kelly & Tali Elfassy & Xiuqing Guo & Walte, 2023. "Evaluating the use of blood pressure polygenic risk scores across race/ethnic background groups," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    2. Surina Singh & Ananyo Choudhury & Scott Hazelhurst & Nigel J. Crowther & Palwendé R. Boua & Hermann Sorgho & Godfred Agongo & Engelbert A. Nonterah & Lisa K. Micklesfield & Shane A. Norris & Isaac Kis, 2023. "Genome-wide association study meta-analysis of blood pressure traits and hypertension in sub-Saharan African populations: an AWI-Gen study," Nature Communications, Nature, vol. 14(1), pages 1-14, December.

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