IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v14y2023i1d10.1038_s41467-023-41196-8.html
   My bibliography  Save this article

Bacterial motility can govern the dynamics of antibiotic resistance evolution

Author

Listed:
  • Vit Piskovsky

    (University of Cambridge
    University of Oxford)

  • Nuno M. Oliveira

    (University of Cambridge
    University of Cambridge)

Abstract

Spatial heterogeneity in antibiotic concentrations is thought to accelerate the evolution of antibiotic resistance, but current theory and experiments have overlooked the effect of cell motility on bacterial adaptation. Here, we study bacterial evolution in antibiotic landscapes with a quantitative model where bacteria evolve under the stochastic processes of proliferation, death, mutation and migration. Numerical and analytical results show that cell motility can both accelerate and decelerate bacterial adaptation by affecting the degree of genotypic mixing and ecological competition. Moreover, we find that for sufficiently high rates, cell motility can limit bacterial survival, and we derive conditions for all these regimes. Similar patterns are observed in more complex scenarios, namely where bacteria can bias their motion in chemical gradients (chemotaxis) or switch between motility phenotypes either stochastically or in a density-dependent manner. Overall, our work reveals limits to bacterial adaptation in antibiotic landscapes that are set by cell motility.

Suggested Citation

  • Vit Piskovsky & Nuno M. Oliveira, 2023. "Bacterial motility can govern the dynamics of antibiotic resistance evolution," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
  • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-41196-8
    DOI: 10.1038/s41467-023-41196-8
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-023-41196-8
    File Function: Abstract
    Download Restriction: no

    File URL: https://libkey.io/10.1038/s41467-023-41196-8?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Souvik Bhattacharyya & David M. Walker & Rasika M. Harshey, 2020. "Dead cells release a ‘necrosignal’ that activates antibiotic survival pathways in bacterial swarms," Nature Communications, Nature, vol. 11(1), pages 1-12, December.
    2. Sebastian Gude & Erçağ Pinçe & Katja M. Taute & Anne-Bart Seinen & Thomas S. Shimizu & Sander J. Tans, 2020. "Bacterial coexistence driven by motility and spatial competition," Nature, Nature, vol. 578(7796), pages 588-592, February.
    3. Nuno M. Oliveira & James H. R. Wheeler & Cyril Deroy & Sean C. Booth & Edmond J. Walsh & William M. Durham & Kevin R. Foster, 2022. "Suicidal chemotaxis in bacteria," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    4. Rene Niehus & Sara Mitri & Alexander G. Fletcher & Kevin R. Foster, 2015. "Migration and horizontal gene transfer divide microbial genomes into multiple niches," Nature Communications, Nature, vol. 6(1), pages 1-9, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Suzanne Humphrey & Alfred Fillol-Salom & Nuria Quiles-Puchalt & Rodrigo Ibarra-Chávez & Andreas F. Haag & John Chen & José R. Penadés, 2021. "Bacterial chromosomal mobility via lateral transduction exceeds that of classical mobile genetic elements," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    2. Pekka Marttinen & William P Hanage, 2017. "Speciation trajectories in recombining bacterial species," PLOS Computational Biology, Public Library of Science, vol. 13(7), pages 1-15, July.
    3. Shiben Zhu & Juken Hong & Teng Wang, 2024. "Horizontal gene transfer is predicted to overcome the diversity limit of competing microbial species," Nature Communications, Nature, vol. 15(1), pages 1-9, December.
    4. Klimenko, Alexandra I. & Matushkin, Yury G. & Kolchanov, Nikolay A. & Lashin, Sergey A., 2019. "Spatial heterogeneity promotes antagonistic evolutionary scenarios in microbial community explained by ecological stratification: a simulation study," Ecological Modelling, Elsevier, vol. 399(C), pages 66-76.
    5. Akshit Goyal, 2018. "Metabolic adaptations underlying genome flexibility in prokaryotes," PLOS Genetics, Public Library of Science, vol. 14(10), pages 1-15, October.
    6. Benjamin Russell Lewis & Muhammad R. Uddin & Mohammad Moniruzzaman & Katie M. Kuo & Anna J. Higgins & Laila M. N. Shah & Frank Sobott & Jerry M. Parks & Dietmar Hammerschmid & James C. Gumbart & Helen, 2023. "Conformational restriction shapes the inhibition of a multidrug efflux adaptor protein," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    7. Manlu Zhu & Xiongfeng Dai, 2024. "Shaping of microbial phenotypes by trade-offs," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    8. Cameron J. Reid & Max L. Cummins & Stefan Börjesson & Michael S. M. Brouwer & Henrik Hasman & Anette M. Hammerum & Louise Roer & Stefanie Hess & Thomas Berendonk & Kristina Nešporová & Marisa Haenni &, 2022. "A role for ColV plasmids in the evolution of pathogenic Escherichia coli ST58," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-41196-8. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.