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Dead cells release a ‘necrosignal’ that activates antibiotic survival pathways in bacterial swarms

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  • Souvik Bhattacharyya

    (University of Texas at Austin)

  • David M. Walker

    (University of Texas at Austin)

  • Rasika M. Harshey

    (University of Texas at Austin)

Abstract

Swarming is a form of collective bacterial motion enabled by flagella on the surface of semi-solid media. Swarming populations exhibit non-genetic or adaptive resistance to antibiotics, despite sustaining considerable cell death. Here, we show that antibiotic-induced death of a sub-population benefits the swarm by enhancing adaptive resistance in the surviving cells. Killed cells release a resistance-enhancing factor that we identify as AcrA, a periplasmic component of RND efflux pumps. The released AcrA interacts on the surface of live cells with an outer membrane component of the efflux pump, TolC, stimulating drug efflux and inducing expression of other efflux pumps. This phenomenon, which we call ‘necrosignaling’, exists in other Gram-negative and Gram-positive bacteria and displays species-specificity. Given that adaptive resistance is a known incubator for evolving genetic resistance, our findings might be clinically relevant to the rise of multidrug resistance.

Suggested Citation

  • Souvik Bhattacharyya & David M. Walker & Rasika M. Harshey, 2020. "Dead cells release a ‘necrosignal’ that activates antibiotic survival pathways in bacterial swarms," Nature Communications, Nature, vol. 11(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-17709-0
    DOI: 10.1038/s41467-020-17709-0
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    Cited by:

    1. Benjamin Russell Lewis & Muhammad R. Uddin & Mohammad Moniruzzaman & Katie M. Kuo & Anna J. Higgins & Laila M. N. Shah & Frank Sobott & Jerry M. Parks & Dietmar Hammerschmid & James C. Gumbart & Helen, 2023. "Conformational restriction shapes the inhibition of a multidrug efflux adaptor protein," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    2. Vit Piskovsky & Nuno M. Oliveira, 2023. "Bacterial motility can govern the dynamics of antibiotic resistance evolution," Nature Communications, Nature, vol. 14(1), pages 1-12, December.

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