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A role for ColV plasmids in the evolution of pathogenic Escherichia coli ST58

Author

Listed:
  • Cameron J. Reid

    (iThree Institute, University of Technology Sydney)

  • Max L. Cummins

    (iThree Institute, University of Technology Sydney)

  • Stefan Börjesson

    (National Veterinary Institute (SVA)
    Public Health Agency of Sweden)

  • Michael S. M. Brouwer

    (Wageningen Bioveterinary Research)

  • Henrik Hasman

    (Statens Serum Institut)

  • Anette M. Hammerum

    (Statens Serum Institut)

  • Louise Roer

    (Statens Serum Institut)

  • Stefanie Hess

    (Technische Universität Dresden)

  • Thomas Berendonk

    (Technische Universität Dresden)

  • Kristina Nešporová

    (CEITEC VETUNI, University of Veterinary Sciences Brno
    University of Veterinary Sciences Brno)

  • Marisa Haenni

    (Université de Lyon-ANSES, Unité Antibiorésistance et Virulence Bactériennes)

  • Jean-Yves Madec

    (Université de Lyon-ANSES, Unité Antibiorésistance et Virulence Bactériennes)

  • Astrid Bethe

    (Freie Universität Berlin
    Freie Universität Berlin)

  • Geovana B. Michael

    (Freie Universität Berlin
    Freie Universität Berlin)

  • Anne-Kathrin Schink

    (Freie Universität Berlin
    Freie Universität Berlin)

  • Stefan Schwarz

    (Freie Universität Berlin
    Freie Universität Berlin)

  • Monika Dolejska

    (CEITEC VETUNI, University of Veterinary Sciences Brno
    University of Veterinary Sciences Brno
    Charles University)

  • Steven P. Djordjevic

    (iThree Institute, University of Technology Sydney)

Abstract

Escherichia coli ST58 has recently emerged as a globally disseminated uropathogen that often progresses to sepsis. Unlike most pandemic extra-intestinal pathogenic E. coli (ExPEC), which belong to pathogenic phylogroup B2, ST58 belongs to the environmental/commensal phylogroup B1. Here, we present a pan-genomic analysis of a global collection of 752 ST58 isolates from diverse sources. We identify a large ST58 sub-lineage characterized by near ubiquitous carriage of ColV plasmids, which carry genes encoding virulence factors, and by a distinct accessory genome including genes typical of the Yersiniabactin High Pathogenicity Island. This sub-lineage includes three-quarters of all ExPEC sequences in our study and has a broad host range, although poultry and porcine sources predominate. By contrast, strains isolated from cattle often lack ColV plasmids. Our data indicate that ColV plasmid acquisition contributed to the divergence of the major ST58 sub-lineage, and different sub-lineages inhabit poultry, swine and cattle.

Suggested Citation

  • Cameron J. Reid & Max L. Cummins & Stefan Börjesson & Michael S. M. Brouwer & Henrik Hasman & Anette M. Hammerum & Louise Roer & Stefanie Hess & Thomas Berendonk & Kristina Nešporová & Marisa Haenni &, 2022. "A role for ColV plasmids in the evolution of pathogenic Escherichia coli ST58," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-28342-4
    DOI: 10.1038/s41467-022-28342-4
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    References listed on IDEAS

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    1. Rene Niehus & Sara Mitri & Alexander G. Fletcher & Kevin R. Foster, 2015. "Migration and horizontal gene transfer divide microbial genomes into multiple niches," Nature Communications, Nature, vol. 6(1), pages 1-9, December.
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    Cited by:

    1. Tamim Khawaja & Tommi Mäklin & Teemu Kallonen & Rebecca A. Gladstone & Anna K. Pöntinen & Sointu Mero & Harry A. Thorpe & Ørjan Samuelsen & Julian Parkhill & Mateen Izhar & M. Waheed Akhtar & Jukka Co, 2024. "Deep sequencing of Escherichia coli exposes colonisation diversity and impact of antibiotics in Punjab, Pakistan," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    2. Guilhem Royer & Olivier Clermont & Julie Marin & Bénédicte Condamine & Sara Dion & François Blanquart & Marco Galardini & Erick Denamur, 2023. "Epistatic interactions between the high pathogenicity island and other iron uptake systems shape Escherichia coli extra-intestinal virulence," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

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