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Bacterial chromosomal mobility via lateral transduction exceeds that of classical mobile genetic elements

Author

Listed:
  • Suzanne Humphrey

    (University of Glasgow)

  • Alfred Fillol-Salom

    (University of Glasgow
    Imperial College London)

  • Nuria Quiles-Puchalt

    (University of Glasgow
    Imperial College London)

  • Rodrigo Ibarra-Chávez

    (University of Glasgow
    University of Copenhagen)

  • Andreas F. Haag

    (University of Glasgow)

  • John Chen

    (Yong Loo Lin School of Medicine, National University of Singapore)

  • José R. Penadés

    (University of Glasgow
    Imperial College London
    Universidad CEU Cardenal Herrera)

Abstract

It is commonly assumed that the horizontal transfer of most bacterial chromosomal genes is limited, in contrast to the frequent transfer observed for typical mobile genetic elements. However, this view has been recently challenged by the discovery of lateral transduction in Staphylococcus aureus, where temperate phages can drive the transfer of large chromosomal regions at extremely high frequencies. Here, we analyse previously published as well as new datasets to compare horizontal gene transfer rates mediated by different mechanisms in S. aureus and Salmonella enterica. We find that the horizontal transfer of core chromosomal genes via lateral transduction can be more efficient than the transfer of classical mobile genetic elements via conjugation or generalized transduction. These results raise questions about our definition of mobile genetic elements, and the potential roles played by lateral transduction in bacterial evolution.

Suggested Citation

  • Suzanne Humphrey & Alfred Fillol-Salom & Nuria Quiles-Puchalt & Rodrigo Ibarra-Chávez & Andreas F. Haag & John Chen & José R. Penadés, 2021. "Bacterial chromosomal mobility via lateral transduction exceeds that of classical mobile genetic elements," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-26004-5
    DOI: 10.1038/s41467-021-26004-5
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    References listed on IDEAS

    as
    1. Alfred Fillol-Salom & Rodrigo Bacigalupe & Suzanne Humphrey & Yin Ning Chiang & John Chen & José R. Penadés, 2021. "Lateral transduction is inherent to the life cycle of the archetypical Salmonella phage P22," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    2. Rene Niehus & Sara Mitri & Alexander G. Fletcher & Kevin R. Foster, 2015. "Migration and horizontal gene transfer divide microbial genomes into multiple niches," Nature Communications, Nature, vol. 6(1), pages 1-9, December.
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    Cited by:

    1. James P. J. Hall, 2021. "Is the bacterial chromosome a mobile genetic element?," Nature Communications, Nature, vol. 12(1), pages 1-4, December.
    2. Alfred Fillol-Salom & Rodrigo Bacigalupe & Suzanne Humphrey & Yin Ning Chiang & John Chen & José R. Penadés, 2021. "Lateral transduction is inherent to the life cycle of the archetypical Salmonella phage P22," Nature Communications, Nature, vol. 12(1), pages 1-12, December.

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