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Tomography of memory engrams in self-organizing nanowire connectomes

Author

Listed:
  • Gianluca Milano

    (INRiM (Istituto Nazionale di Ricerca Metrologica))

  • Alessandro Cultrera

    (INRiM (Istituto Nazionale di Ricerca Metrologica))

  • Luca Boarino

    (INRiM (Istituto Nazionale di Ricerca Metrologica))

  • Luca Callegaro

    (INRiM (Istituto Nazionale di Ricerca Metrologica))

  • Carlo Ricciardi

    (Politecnico di Torino)

Abstract

Self-organizing memristive nanowire connectomes have been exploited for physical (in materia) implementation of brain-inspired computing paradigms. Despite having been shown that the emergent behavior relies on weight plasticity at single junction/synapse level and on wiring plasticity involving topological changes, a shift to multiterminal paradigms is needed to unveil dynamics at the network level. Here, we report on tomographical evidence of memory engrams (or memory traces) in nanowire connectomes, i.e., physicochemical changes in biological neural substrates supposed to endow the representation of experience stored in the brain. An experimental/modeling approach shows that spatially correlated short-term plasticity effects can turn into long-lasting engram memory patterns inherently related to network topology inhomogeneities. The ability to exploit both encoding and consolidation of information on the same physical substrate would open radically new perspectives for in materia computing, while offering to neuroscientists an alternative platform to understand the role of memory in learning and knowledge.

Suggested Citation

  • Gianluca Milano & Alessandro Cultrera & Luca Boarino & Luca Callegaro & Carlo Ricciardi, 2023. "Tomography of memory engrams in self-organizing nanowire connectomes," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
  • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-40939-x
    DOI: 10.1038/s41467-023-40939-x
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    References listed on IDEAS

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    1. Ruomin Zhu & Sam Lilak & Alon Loeffler & Joseph Lizier & Adam Stieg & James Gimzewski & Zdenka Kuncic, 2023. "Online dynamical learning and sequence memory with neuromorphic nanowire networks," Nature Communications, Nature, vol. 14(1), pages 1-12, December.

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