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Synaptic computation

Author

Listed:
  • L. F. Abbott

    (Brandeis University)

  • Wade G. Regehr

    (Harvard Medical School)

Abstract

Neurons are often considered to be the computational engines of the brain, with synapses acting solely as conveyers of information. But the diverse types of synaptic plasticity and the range of timescales over which they operate suggest that synapses have a more active role in information processing. Long-term changes in the transmission properties of synapses provide a physiological substrate for learning and memory, whereas short-term changes support a variety of computations. By expressing several forms of synaptic plasticity, a single neuron can convey an array of different signals to the neural circuit in which it operates.

Suggested Citation

  • L. F. Abbott & Wade G. Regehr, 2004. "Synaptic computation," Nature, Nature, vol. 431(7010), pages 796-803, October.
    • Handle: RePEc:nat:nature:v:431:y:2004:i:7010:d:10.1038_nature03010
    DOI: 10.1038/nature03010
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    Cited by:

    1. Marieke Meijer & Miriam Öttl & Jie Yang & Aygul Subkhangulova & Avinash Kumar & Zicheng Feng & Torben W. Voorst & Alexander J. Groffen & Jan R. T. Weering & Yongli Zhang & Matthijs Verhage, 2024. "Tomosyns attenuate SNARE assembly and synaptic depression by binding to VAMP2-containing template complexes," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    2. He-Shan Zhang & Xue-Mei Dong & Zi-Cheng Zhang & Ze-Pu Zhang & Chao-Yi Ban & Zhe Zhou & Cheng Song & Shi-Qi Yan & Qian Xin & Ju-Qing Liu & Yin-Xiang Li & Wei Huang, 2022. "Co-assembled perylene/graphene oxide photosensitive heterobilayer for efficient neuromorphics," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
    3. Philipe R. F. Mendonça & Erica Tagliatti & Helen Langley & Dimitrios Kotzadimitriou & Criseida G. Zamora-Chimal & Yulia Timofeeva & Kirill E. Volynski, 2022. "Asynchronous glutamate release is enhanced in low release efficacy synapses and dispersed across the active zone," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    4. Gianluca Milano & Alessandro Cultrera & Luca Boarino & Luca Callegaro & Carlo Ricciardi, 2023. "Tomography of memory engrams in self-organizing nanowire connectomes," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    5. A. Barri & M. T. Wiechert & M. Jazayeri & D. A. DiGregorio, 2022. "Synaptic basis of a sub-second representation of time in a neural circuit model," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    6. Elisa Donati & Giacomo Valle, 2024. "Neuromorphic hardware for somatosensory neuroprostheses," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    7. Giacomo Valle & Natalija Katic Secerovic & Dominic Eggemann & Oleg Gorskii & Natalia Pavlova & Francesco M. Petrini & Paul Cvancara & Thomas Stieglitz & Pavel Musienko & Marko Bumbasirevic & Stanisa R, 2024. "Biomimetic computer-to-brain communication enhancing naturalistic touch sensations via peripheral nerve stimulation," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    8. Zhou, Xinjia & Zhang, Yan & Gu, Tianyi & Zheng, Muhua & Xu, Kesheng, 2024. "Mixed synaptic modulation and inhibitory plasticity perform complementary roles in metastable transitions," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 635(C).
    9. Protachevicz, Paulo R. & Batista, Antonio M. & Caldas, Iberê L. & Baptista, Murilo S., 2024. "Analytical solutions for the short-term plasticity," Chaos, Solitons & Fractals, Elsevier, vol. 181(C).
    10. Zhou, Xinjia & Tian, Changhai & Zhang, Xiyun & Zheng, Muhua & Xu, Kesheng, 2022. "Short-term plasticity as a mechanism to regulate and retain multistability," Chaos, Solitons & Fractals, Elsevier, vol. 165(P1).

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