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Involvement of skin TRPV3 in temperature detection regulated by TMEM79 in mice

Author

Listed:
  • Jing Lei

    (National Institutes of Natural Sciences
    The Graduate University for Advanced Studies (SOKENDAI)
    National Institutes of Natural Sciences)

  • Reiko U. Yoshimoto

    (Saga University)

  • Takeshi Matsui

    (RIKEN Center for Integrative Medical Sciences
    Tokyo University of Technology
    Keio University School of Medicine)

  • Masayuki Amagai

    (RIKEN Center for Integrative Medical Sciences
    Keio University School of Medicine)

  • Mizuho A. Kido

    (Saga University)

  • Makoto Tominaga

    (National Institutes of Natural Sciences
    The Graduate University for Advanced Studies (SOKENDAI)
    National Institutes of Natural Sciences)

Abstract

TRPV3, a non-selective cation transient receptor potential (TRP) ion channel, is activated by warm temperatures. It is predominantly expressed in skin keratinocytes, and participates in various somatic processes. Previous studies have reported that thermosensation in mice lacking TRPV3 was impaired. Here, we identified a transmembrane protein, TMEM79, that acts as a negative regulator of TRPV3. Heterologous expression of TMEM79 was capable of suppressing TRPV3-mediated currents in HEK293T cells. In addition, TMEM79 modulated TRPV3 translocalization and promoted its degradation in the lysosomes. TRPV3-mediated currents and Ca2+ influx were potentiated in primary mouse keratinocytes lacking TMEM79. Furthermore, TMEM79-deficient male mice preferred a higher temperature than did wild-type mice due to elevated TRPV3 function. Our study revealed unique interactions between TRPV3 and TMEM79, both in vitro and in vivo. These findings support roles for TMEM79 and TRPV3 in thermosensation.

Suggested Citation

  • Jing Lei & Reiko U. Yoshimoto & Takeshi Matsui & Masayuki Amagai & Mizuho A. Kido & Makoto Tominaga, 2023. "Involvement of skin TRPV3 in temperature detection regulated by TMEM79 in mice," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-39712-x
    DOI: 10.1038/s41467-023-39712-x
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