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TRPV3 regulates nitric oxide synthase-independent nitric oxide synthesis in the skin

Author

Listed:
  • Takashi Miyamoto

    (Dorris Neuroscience Center, The Scripps Research Institute)

  • Matt J. Petrus

    (Genomics Institute of the Novartis Research Foundation)

  • Adrienne E. Dubin

    (Dorris Neuroscience Center, The Scripps Research Institute)

  • Ardem Patapoutian

    (Dorris Neuroscience Center, The Scripps Research Institute
    Genomics Institute of the Novartis Research Foundation)

Abstract

Nitric oxide (NO) is an unstable signalling molecule synthesized de novo mainly from L-arginine by NO synthase (NOS) enzymes. Nitrite reduction can also produce NO, predominantly within body fluids (for example, saliva, sweat and blood plasma) and under extreme hypoxic and acidic conditions. It remains unknown if intracellular canonical signalling pathways regulate nitrite-dependent NO production. Here we examine NO production in the skin, a hypoxic tissue enriched in nitrites wherein NO has important roles in wound healing and other biological processes. We show that activation of TRPV3, a heat-activated transient receptor potential ion channel expressed in keratinocytes, induces NO production via a nitrite-dependent pathway. TRPV3 and nitrite are involved in keratinocyte migration in vitro and in wound healing and thermosensory behaviours in vivo. Our study demonstrates that activation of an ion channel can induce NOS-independent NO production in keratinocytes.

Suggested Citation

  • Takashi Miyamoto & Matt J. Petrus & Adrienne E. Dubin & Ardem Patapoutian, 2011. "TRPV3 regulates nitric oxide synthase-independent nitric oxide synthesis in the skin," Nature Communications, Nature, vol. 2(1), pages 1-12, September.
    • Handle: RePEc:nat:natcom:v:2:y:2011:i:1:d:10.1038_ncomms1371
    DOI: 10.1038/ncomms1371
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    Cited by:

    1. Arthur Neuberger & Kirill D. Nadezhdin & Alexander I. Sobolevsky, 2022. "Structural mechanism of TRPV3 channel inhibition by the anesthetic dyclonine," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
    2. Jing Lei & Reiko U. Yoshimoto & Takeshi Matsui & Masayuki Amagai & Mizuho A. Kido & Makoto Tominaga, 2023. "Involvement of skin TRPV3 in temperature detection regulated by TMEM79 in mice," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

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