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TRPV3 is a calcium-permeable temperature-sensitive cation channel

Author

Listed:
  • Haoxing Xu

    (Howard Hughes Medical Institute, Children's Hospital, Harvard Medical School)

  • I. Scott Ramsey

    (Howard Hughes Medical Institute, Children's Hospital, Harvard Medical School)

  • Suhas A. Kotecha

    (Howard Hughes Medical Institute, Children's Hospital, Harvard Medical School)

  • Magdalene M. Moran

    (Harvard Medical School)

  • Jayhong A. Chong

    (Howard Hughes Medical Institute, Children's Hospital, Harvard Medical School)

  • Deborah Lawson

    (Millennium Pharmaceuticals Inc.)

  • Pei Ge

    (Millennium Pharmaceuticals Inc.)

  • Jeremiah Lilly

    (Millennium Pharmaceuticals Inc.)

  • Inmaculada Silos-Santiago

    (Millennium Pharmaceuticals Inc.)

  • Yu Xie

    (Millennium Pharmaceuticals Inc.)

  • Peter S. DiStefano

    (Millennium Pharmaceuticals Inc.
    Elixir Pharmaceuticals Inc.)

  • Rory Curtis

    (Millennium Pharmaceuticals Inc.
    Elixir Pharmaceuticals Inc.)

  • David E. Clapham

    (Howard Hughes Medical Institute, Children's Hospital, Harvard Medical School)

Abstract

Transient receptor potential (TRP) proteins are cation-selective channels that function in processes as diverse as sensation and vasoregulation. Mammalian TRP channels that are gated by heat and capsaicin (>43 °C; TRPV1 (ref. 1)), noxious heat (>52 °C; TRPV2 (ref. 2)), and cooling (

Suggested Citation

  • Haoxing Xu & I. Scott Ramsey & Suhas A. Kotecha & Magdalene M. Moran & Jayhong A. Chong & Deborah Lawson & Pei Ge & Jeremiah Lilly & Inmaculada Silos-Santiago & Yu Xie & Peter S. DiStefano & Rory Curt, 2002. "TRPV3 is a calcium-permeable temperature-sensitive cation channel," Nature, Nature, vol. 418(6894), pages 181-186, July.
    • Handle: RePEc:nat:nature:v:418:y:2002:i:6894:d:10.1038_nature00882
    DOI: 10.1038/nature00882
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    Cited by:

    1. Jing Lei & Reiko U. Yoshimoto & Takeshi Matsui & Masayuki Amagai & Mizuho A. Kido & Makoto Tominaga, 2023. "Involvement of skin TRPV3 in temperature detection regulated by TMEM79 in mice," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    2. Arthur Neuberger & Kirill D. Nadezhdin & Alexander I. Sobolevsky, 2022. "Structural mechanism of TRPV3 channel inhibition by the anesthetic dyclonine," Nature Communications, Nature, vol. 13(1), pages 1-9, December.

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