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The menthol receptor TRPM8 is the principal detector of environmental cold

Author

Listed:
  • Diana M. Bautista

    (Department of Physiology,
    Department of Cellular and Molecular Pharmacology,)

  • Jan Siemens

    (Department of Physiology,
    Department of Cellular and Molecular Pharmacology,)

  • Joshua M. Glazer

    (Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA)

  • Pamela R. Tsuruda

    (Department of Physiology,
    Department of Cellular and Molecular Pharmacology,)

  • Allan I. Basbaum

    (Departments of Anatomy and Physiology,
    W. M. Keck Center for Integrative Neuroscience, University of California, San Francisco, California 94143, USA)

  • Cheryl L. Stucky

    (Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA)

  • Sven-Eric Jordt

    (Yale University School of Medicine, New Haven, Connecticut 06520, USA)

  • David Julius

    (Department of Physiology,
    Department of Cellular and Molecular Pharmacology,)

Abstract

A chilly receptor A variety of different ion channels have been suggested to underlie the detection of cold stimuli, and the role of each of these in detecting innocuous cool versus noxious cold has been much debated. The menthol receptor TRPM8 is a strong candidate as a cold transducer, but its physiological importance has been questioned. A study of cold sensitivity in TRPM8 knockout mice has clarified matters. Mice lacking the receptor are deficient in the ability to sense cold at the cellular level, in intact nerve fibres and in whole animal (behavioural) tests. TRPM8 is clearly the primary contributor to peripheral cold sensation, with animals lacking this channel unable to discriminate between warm and cold surfaces until the temperature drops to below 10 °C.

Suggested Citation

  • Diana M. Bautista & Jan Siemens & Joshua M. Glazer & Pamela R. Tsuruda & Allan I. Basbaum & Cheryl L. Stucky & Sven-Eric Jordt & David Julius, 2007. "The menthol receptor TRPM8 is the principal detector of environmental cold," Nature, Nature, vol. 448(7150), pages 204-208, July.
    • Handle: RePEc:nat:nature:v:448:y:2007:i:7150:d:10.1038_nature05910
    DOI: 10.1038/nature05910
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    Cited by:

    1. Erick Olivares & Simón Salgado & Jean Paul Maidana & Gaspar Herrera & Matías Campos & Rodolfo Madrid & Patricio Orio, 2015. "TRPM8-Dependent Dynamic Response in a Mathematical Model of Cold Thermoreceptor," PLOS ONE, Public Library of Science, vol. 10(10), pages 1-17, October.
    2. David Alarcón-Alarcón & David Cabañero & Jorge Andrés-López & Magdalena Nikolaeva-Koleva & Simona Giorgi & Gregorio Fernández-Ballester & Asia Fernández-Carvajal & Antonio Ferrer-Montiel, 2022. "TRPM8 contributes to sex dimorphism by promoting recovery of normal sensitivity in a mouse model of chronic migraine," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    3. Chang-Hyung Lee & Young-A Choi & Sung-Jin Heo & Parkyong Song, 2021. "The Effect of Hyperbaric Therapy on Brown Adipose Tissue in Rats," IJERPH, MDPI, vol. 18(17), pages 1-8, August.
    4. WHO Study Group on Tobacco Product Regulation (TobReg), 2016. "Advisory note: banning menthol in tobacco products," University of California at San Francisco, Center for Tobacco Control Research and Education qt8td7w55n, Center for Tobacco Control Research and Education, UC San Francisco.
    5. Ivo B. Regli & Giacomo Strapazzon & Marika Falla & Rosmarie Oberhammer & Hermann Brugger, 2021. "Long-Term Sequelae of Frostbite—A Scoping Review," IJERPH, MDPI, vol. 18(18), pages 1-16, September.
    6. Jing Lei & Reiko U. Yoshimoto & Takeshi Matsui & Masayuki Amagai & Mizuho A. Kido & Makoto Tominaga, 2023. "Involvement of skin TRPV3 in temperature detection regulated by TMEM79 in mice," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

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