PHGDH arginine methylation by PRMT1 promotes serine synthesis and represents a therapeutic vulnerability in hepatocellular carcinoma
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DOI: 10.1038/s41467-023-36708-5
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- Mylène Tajan & Marc Hennequart & Eric C. Cheung & Fabio Zani & Andreas K. Hock & Nathalie Legrave & Oliver D. K. Maddocks & Rachel A. Ridgway & Dimitris Athineos & Alejandro Suárez-Bonnet & Robert L. , 2021. "Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy," Nature Communications, Nature, vol. 12(1), pages 1-16, December.
- Richard Possemato & Kevin M. Marks & Yoav D. Shaul & Michael E. Pacold & Dohoon Kim & Kıvanç Birsoy & Shalini Sethumadhavan & Hin-Koon Woo & Hyun G. Jang & Abhishek K. Jha & Walter W. Chen & Francesca, 2011. "Functional genomics reveal that the serine synthesis pathway is essential in breast cancer," Nature, Nature, vol. 476(7360), pages 346-350, August.
- Takehiro Yamamoto & Naoharu Takano & Kyoko Ishiwata & Mitsuyo Ohmura & Yoshiko Nagahata & Tomomi Matsuura & Aki Kamata & Kyoko Sakamoto & Tsuyoshi Nakanishi & Akiko Kubo & Takako Hishiki & Makoto Suem, 2014. "Reduced methylation of PFKFB3 in cancer cells shunts glucose towards the pentose phosphate pathway," Nature Communications, Nature, vol. 5(1), pages 1-16, May.
- Thangaselvam Muthusamy & Thekla Cordes & Michal K. Handzlik & Le You & Esther W. Lim & Jivani Gengatharan & Antonio F. M. Pinto & Mehmet G. Badur & Matthew J. Kolar & Martina Wallace & Alan Saghatelia, 2020. "Serine restriction alters sphingolipid diversity to constrain tumour growth," Nature, Nature, vol. 586(7831), pages 790-795, October.
- Yuan Liu & Ji-Zheng Guo & Ying Liu & Kui Wang & Wencheng Ding & Hui Wang & Xiang Liu & Shengtao Zhou & Xiao-Chen Lu & Hong-Bin Yang & Chenyue Xu & Wei Gao & Li Zhou & Yi-Ping Wang & Weiguo Hu & Yuquan, 2018. "Nuclear lactate dehydrogenase A senses ROS to produce α-hydroxybutyrate for HPV-induced cervical tumor growth," Nature Communications, Nature, vol. 9(1), pages 1-16, December.
- Matteo Rossi & Patricia Altea-Manzano & Margherita Demicco & Ginevra Doglioni & Laura Bornes & Marina Fukano & Anke Vandekeere & Alejandro M. Cuadros & Juan Fernández-García & Carla Riera-Domingo & Cr, 2022. "Author Correction: PHGDH heterogeneity potentiates cancer cell dissemination and metastasis," Nature, Nature, vol. 609(7927), pages 8-8, September.
- Michael A. Reid & Annamarie E. Allen & Shiyu Liu & Maria V. Liberti & Pei Liu & Xiaojing Liu & Ziwei Dai & Xia Gao & Qian Wang & Ying Liu & Luhua Lai & Jason W. Locasale, 2018. "Serine synthesis through PHGDH coordinates nucleotide levels by maintaining central carbon metabolism," Nature Communications, Nature, vol. 9(1), pages 1-11, December.
- Matteo Rossi & Patricia Altea-Manzano & Margherita Demicco & Ginevra Doglioni & Laura Bornes & Marina Fukano & Anke Vandekeere & Alejandro M. Cuadros & Juan Fernández-García & Carla Riera-Domingo & Cr, 2022. "PHGDH heterogeneity potentiates cancer cell dissemination and metastasis," Nature, Nature, vol. 605(7911), pages 747-753, May.
- Lai Wei & Derek Lee & Cheuk-Ting Law & Misty Shuo Zhang & Jialing Shen & Don Wai-Ching Chin & Allen Zhang & Felice Ho-Ching Tsang & Ceci Lok-Sze Wong & Irene Oi-Lin Ng & Carmen Chak-Lui Wong & Chun-Mi, 2019. "Genome-wide CRISPR/Cas9 library screening identified PHGDH as a critical driver for Sorafenib resistance in HCC," Nature Communications, Nature, vol. 10(1), pages 1-13, December.
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- Li Luo & Xingyun Wu & Jiawu Fan & Lixia Dong & Mao Wang & Yan Zeng & Sijia Li & Wenyong Yang & Jingwen Jiang & Kui Wang, 2024. "FBXO7 ubiquitinates PRMT1 to suppress serine synthesis and tumor growth in hepatocellular carcinoma," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
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