Tryptophan fuels MYC-dependent liver tumorigenesis through indole 3-pyruvate synthesis
Author
Abstract
Suggested Citation
DOI: 10.1038/s41467-024-47868-3
Download full text from publisher
References listed on IDEAS
- Thangaselvam Muthusamy & Thekla Cordes & Michal K. Handzlik & Le You & Esther W. Lim & Jivani Gengatharan & Antonio F. M. Pinto & Mehmet G. Badur & Matthew J. Kolar & Martina Wallace & Alan Saghatelia, 2020. "Serine restriction alters sphingolipid diversity to constrain tumour growth," Nature, Nature, vol. 586(7831), pages 790-795, October.
- Evan C. Lien & Anna M. Westermark & Yin Zhang & Chen Yuan & Zhaoqi Li & Allison N. Lau & Kiera M. Sapp & Brian M. Wolpin & Matthew G. Vander Heiden, 2021. "Low glycaemic diets alter lipid metabolism to influence tumour growth," Nature, Nature, vol. 599(7884), pages 302-307, November.
- Abhijeet Pataskar & Julien Champagne & Remco Nagel & Juliana Kenski & Maarja Laos & Justine Michaux & Hui Song Pak & Onno B. Bleijerveld & Kelly Mordente & Jasmine Montenegro Navarro & Naomi Blommaert, 2022. "Tryptophan depletion results in tryptophan-to-phenylalanine substitutants," Nature, Nature, vol. 603(7902), pages 721-727, March.
- Xia Gao & Sydney M. Sanderson & Ziwei Dai & Michael A. Reid & Daniel E. Cooper & Min Lu & John P. Richie & Amy Ciccarella & Ana Calcagnotto & Peter G. Mikhael & Samantha J. Mentch & Juan Liu & Gene Ab, 2019. "Dietary methionine influences therapy in mouse cancer models and alters human metabolism," Nature, Nature, vol. 572(7769), pages 397-401, August.
- Abhijeet Pataskar & Julien Champagne & Remco Nagel & Juliana Kenski & Maarja Laos & Justine Michaux & Hui Song Pak & Onno B. Bleijerveld & Kelly Mordente & Jasmine Montenegro Navarro & Naomi Blommaert, 2022. "Author Correction: Tryptophan depletion results in tryptophan-to-phenylalanine substitutants," Nature, Nature, vol. 608(7922), pages 20-20, August.
- Catherine M. Shachaf & Andrew M. Kopelman & Constadina Arvanitis & Åsa Karlsson & Shelly Beer & Stefanie Mandl & Michael H. Bachmann & Alexander D. Borowsky & Boris Ruebner & Robert D. Cardiff & Qiwei, 2004. "MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer," Nature, Nature, vol. 431(7012), pages 1112-1117, October.
- Christiane A. Opitz & Ulrike M. Litzenburger & Felix Sahm & Martina Ott & Isabel Tritschler & Saskia Trump & Theresa Schumacher & Leonie Jestaedt & Dieter Schrenk & Michael Weller & Manfred Jugold & G, 2011. "An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor," Nature, Nature, vol. 478(7368), pages 197-203, October.
Most related items
These are the items that most often cite the same works as this one and are cited by the same works as this one.- Bo Wen & Bing Zhang, 2023. "PepQuery2 democratizes public MS proteomics data for rapid peptide searching," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
- Yanjie Tan & Zhenzhou Huang & Yi Jin & Jiaying Wang & Hongjun Fan & Yangyang Liu & Liang Zhang & Yue Wu & Peiwei Liu & Tianliang Li & Jie Ran & He Tian & Sin Man Lam & Min Liu & Jun Zhou & Yunfan Yang, 2024. "Lipid droplets sequester palmitic acid to disrupt endothelial ciliation and exacerbate atherosclerosis in male mice," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
- Donghong Zhang & Jinfeng Ning & Tharmarajan Ramprasath & Changjiang Yu & Xiaoxu Zheng & Ping Song & Zhonglin Xie & Ming-Hui Zou, 2022. "Kynurenine promotes neonatal heart regeneration by stimulating cardiomyocyte proliferation and cardiac angiogenesis," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
- Kui Wang & Li Luo & Shuyue Fu & Mao Wang & Zihao Wang & Lixia Dong & Xingyun Wu & Lunzhi Dai & Yong Peng & Guobo Shen & Hai-Ning Chen & Edouard Collins Nice & Xiawei Wei & Canhua Huang, 2023. "PHGDH arginine methylation by PRMT1 promotes serine synthesis and represents a therapeutic vulnerability in hepatocellular carcinoma," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
- Hanyu Rao & Changwei Liu & Aiting Wang & Chunxiao Ma & Yue Xu & Tianbao Ye & Wenqiong Su & Peijun Zhou & Wei-Qiang Gao & Li Li & Xianting Ding, 2023. "SETD2 deficiency accelerates sphingomyelin accumulation and promotes the development of renal cancer," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
- Ziwei Dai & Weiyan Zheng & Jason W. Locasale, 2022. "Amino acid variability, tradeoffs and optimality in human diet," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
- Ziheng Chen & I-Lin Ho & Melinda Soeung & Er-Yen Yen & Jintan Liu & Liang Yan & Johnathon L. Rose & Sanjana Srinivasan & Shan Jiang & Q. Edward Chang & Ningping Feng & Jason P. Gay & Qi Wang & Jing Wa, 2023. "Ether phospholipids are required for mitochondrial reactive oxygen species homeostasis," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
- Yun Seok Kim & Bongsub Ko & Da Jung Kim & Jihoon Tak & Chang Yeob Han & Joo-Youn Cho & Won Kim & Sang Geon Kim, 2022. "Induction of the hepatic aryl hydrocarbon receptor by alcohol dysregulates autophagy and phospholipid metabolism via PPP2R2D," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
- Anja Deutzmann & Delaney K. Sullivan & Renumathy Dhanasekaran & Wei Li & Xinyu Chen & Ling Tong & Wadie D. Mahauad-Fernandez & John Bell & Adriane Mosley & Angela N. Koehler & Yulin Li & Dean W. Felsh, 2024. "Nuclear to cytoplasmic transport is a druggable dependency in MYC-driven hepatocellular carcinoma," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
- Philipp Hammerschmidt & Sophie M. Steculorum & Cécile L. Bandet & Almudena Río-Martín & Lukas Steuernagel & Vivien Kohlhaas & Marvin Feldmann & Luis Varela & Adam Majcher & Marta Quatorze Correia & Rh, 2023. "CerS6-dependent ceramide synthesis in hypothalamic neurons promotes ER/mitochondrial stress and impairs glucose homeostasis in obese mice," Nature Communications, Nature, vol. 14(1), pages 1-22, December.
- Pravin Kesarwani & Shiva Kant & Yi Zhao & Antony Prabhu & Katie L. Buelow & C. Ryan Miller & Prakash Chinnaiyan, 2023. "Quinolinate promotes macrophage-induced immune tolerance in glioblastoma through the NMDAR/PPARγ signaling axis," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
- Alessia Cacciatore & Dheeraj Shinde & Carola Musumeci & Giada Sandrini & Luca Guarrera & Domenico Albino & Gianluca Civenni & Elisa Storelli & Simone Mosole & Elisa Federici & Alessio Fusina & Marta I, 2024. "Epigenome-wide impact of MAT2A sustains the androgen-indifferent state and confers synthetic vulnerability in ERG fusion-positive prostate cancer," Nature Communications, Nature, vol. 15(1), pages 1-25, December.
- Bo Wang & Jing Chen & Julia S. Caserto & Xi Wang & Minglin Ma, 2022. "An in situ hydrogel-mediated chemo-immunometabolic cancer therapy," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
- Zidan Wang & Donghui Zhang & Junhan Wu & Wenpeng Zhang & Yu Xia, 2024. "Illuminating the dark space of neutral glycosphingolipidome by selective enrichment and profiling at multi-structural levels," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
Corrections
All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-47868-3. See general information about how to correct material in RePEc.
If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.
If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .
If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.
For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .
Please note that corrections may take a couple of weeks to filter through the various RePEc services.