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In-situ cryo-immune engineering of tumor microenvironment with cold-responsive nanotechnology for cancer immunotherapy

Author

Listed:
  • Wenquan Ou

    (University of Maryland)

  • Samantha Stewart

    (University of Maryland)

  • Alisa White

    (University of Maryland)

  • Elyahb A. Kwizera

    (University of Maryland)

  • Jiangsheng Xu

    (University of Maryland)

  • Yuanzhang Fang

    (Indiana University School of Medicine)

  • James G. Shamul

    (University of Maryland)

  • Changqing Xie

    (National Institutes of Health)

  • Suliat Nurudeen

    (University of Maryland)

  • Nikki P. Tirada

    (University of Maryland)

  • Xiongbin Lu

    (Indiana University School of Medicine)

  • Katherine H. R. Tkaczuk

    (University of Maryland)

  • Xiaoming He

    (University of Maryland
    University of Maryland)

Abstract

Cancer immunotherapy that deploys the host’s immune system to recognize and attack tumors, is a promising strategy for cancer treatment. However, its efficacy is greatly restricted by the immunosuppressive (i.e., immunologically cold) tumor microenvironment (TME). Here, we report an in-situ cryo-immune engineering (ICIE) strategy for turning the TME from immunologically “cold” into “hot”. In particular, after the ICIE treatment, the ratio of the CD8+ cytotoxic T cells to the immunosuppressive regulatory T cells is increased by more than 100 times in not only the primary tumors with cryosurgery but also distant tumors without freezing. This is achieved by combining cryosurgery that causes “frostbite” of tumor with cold-responsive nanoparticles that not only target tumor but also rapidly release both anticancer drug and PD-L1 silencing siRNA specifically into the cytosol upon cryosurgery. This ICIE treatment leads to potent immunogenic cell death, which promotes maturation of dendritic cells and activation of CD8+ cytotoxic T cells as well as memory T cells to kill not only primary but also distant/metastatic breast tumors in female mice (i.e., the abscopal effect). Collectively, ICIE may enable an efficient and durable way to leverage the immune system for combating cancer and its metastasis.

Suggested Citation

  • Wenquan Ou & Samantha Stewart & Alisa White & Elyahb A. Kwizera & Jiangsheng Xu & Yuanzhang Fang & James G. Shamul & Changqing Xie & Suliat Nurudeen & Nikki P. Tirada & Xiongbin Lu & Katherine H. R. T, 2023. "In-situ cryo-immune engineering of tumor microenvironment with cold-responsive nanotechnology for cancer immunotherapy," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
  • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-36045-7
    DOI: 10.1038/s41467-023-36045-7
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    References listed on IDEAS

    as
    1. Ira Mellman & George Coukos & Glenn Dranoff, 2011. "Cancer immunotherapy comes of age," Nature, Nature, vol. 480(7378), pages 480-489, December.
    2. Yuling Xiao & Jiang Chen & Hui Zhou & Xiaodong Zeng & Zhiping Ruan & Zhangya Pu & Xingya Jiang & Aya Matsui & Lingling Zhu & Zohreh Amoozgar & Dean Shuailin Chen & Xiangfei Han & Dan G. Duda & Jinjun , 2022. "Combining p53 mRNA nanotherapy with immune checkpoint blockade reprograms the immune microenvironment for effective cancer therapy," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
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    1. Yinying Pu & Bangguo Zhou & Jinhong Bing & Liang Wang & Mingqi Chen & Yucui Shen & Shuang Gao & Min Zhou & Wencheng Wu & Jianlin Shi, 2024. "Ultrasound-triggered and glycosylation inhibition-enhanced tumor piezocatalytic immunotherapy," Nature Communications, Nature, vol. 15(1), pages 1-20, December.

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