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Ultrasound-triggered and glycosylation inhibition-enhanced tumor piezocatalytic immunotherapy

Author

Listed:
  • Yinying Pu

    (Chinese Academy of Sciences
    University of Electronic Science and Technology of China)

  • Bangguo Zhou

    (Zhejiang University)

  • Jinhong Bing

    (Chinese Academy of Sciences)

  • Liang Wang

    (Chinese Academy of Sciences)

  • Mingqi Chen

    (Shanghai Fourth People’s Hospital to Tongji University)

  • Yucui Shen

    (Shanghai Fourth People’s Hospital to Tongji University)

  • Shuang Gao

    (Shanghai Fourth People’s Hospital to Tongji University)

  • Min Zhou

    (Shanghai Fourth People’s Hospital to Tongji University)

  • Wencheng Wu

    (Chinese Academy of Sciences
    University of Electronic Science and Technology of China)

  • Jianlin Shi

    (Chinese Academy of Sciences)

Abstract

Nanocatalytic immunotherapy holds excellent potential for future cancer therapy due to its rapid activation of the immune system to attack tumor cells. However, a high level of N-glycosylation can protect tumor cells, compromising the anticancer immunity of nanocatalytic immunotherapy. Here, we show a 2-deoxyglucose (2-DG) and bismuth ferrite co-loaded gel (DBG) scaffold for enhanced cancer piezocatalytic immunotherapy. After the implantation in the tumor, DBG generates both reactive oxygen species (ROS) and piezoelectric signals when excited with ultrasound irradiation, significantly promoting the activation of anticancer immunity. Meanwhile, 2-DG released from ROS-sensitive DBG disrupts the N-glycans synthesis, further overcoming the immunosuppressive microenvironment of tumors. The synergy effects of ultrasound-triggered and glycosylation inhibition enhanced tumor piezocatalytic immunotherapy are demonstrated on four mouse cancer models. A “hot” tumor-immunity niche is produced to inhibit tumor progress and lung metastasis and elicit strong immune memory effects. This work provides a promising piezocatalytic immunotherapy for malignant solid tumors featuring both low immunogenicity and high levels of N-glycosylation.

Suggested Citation

  • Yinying Pu & Bangguo Zhou & Jinhong Bing & Liang Wang & Mingqi Chen & Yucui Shen & Shuang Gao & Min Zhou & Wencheng Wu & Jianlin Shi, 2024. "Ultrasound-triggered and glycosylation inhibition-enhanced tumor piezocatalytic immunotherapy," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-53392-1
    DOI: 10.1038/s41467-024-53392-1
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    References listed on IDEAS

    as
    1. Jifeng Yu & Bangguo Zhou & Shen Zhang & Haohao Yin & Liping Sun & Yinying Pu & Boyang Zhou & Yikang Sun & Xiaolong Li & Yan Fang & Lifan Wang & Chongke Zhao & Dou Du & Yan Zhang & Huixiong Xu, 2022. "Design of a self-driven probiotic-CRISPR/Cas9 nanosystem for sono-immunometabolic cancer therapy," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
    2. K. Hayashi & F. Nikolos & Y. C. Lee & A. Jain & E. Tsouko & H. Gao & A. Kasabyan & H. E. Leung & A. Osipov & S. Y. Jung & A. V. Kurtova & K. S. Chan, 2020. "Tipping the immunostimulatory and inhibitory DAMP balance to harness immunogenic cell death," Nature Communications, Nature, vol. 11(1), pages 1-13, December.
    3. Yonghyun Lee & Jongyoon Shinn & Cheng Xu & Hannah E. Dobson & Nouri Neamati & James J. Moon, 2023. "Hyaluronic acid-bilirubin nanomedicine-based combination chemoimmunotherapy," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    4. Wenquan Ou & Samantha Stewart & Alisa White & Elyahb A. Kwizera & Jiangsheng Xu & Yuanzhang Fang & James G. Shamul & Changqing Xie & Suliat Nurudeen & Nikki P. Tirada & Xiongbin Lu & Katherine H. R. T, 2023. "In-situ cryo-immune engineering of tumor microenvironment with cold-responsive nanotechnology for cancer immunotherapy," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
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