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Sensory nerve niche regulates mesenchymal stem cell homeostasis via FGF/mTOR/autophagy axis

Author

Listed:
  • Fei Pei

    (University of Southern California
    Wuhan University)

  • Li Ma

    (University of Southern California)

  • Junjun Jing

    (University of Southern California)

  • Jifan Feng

    (University of Southern California)

  • Yuan Yuan

    (University of Southern California)

  • Tingwei Guo

    (University of Southern California)

  • Xia Han

    (University of Southern California)

  • Thach-Vu Ho

    (University of Southern California)

  • Jie Lei

    (University of Southern California)

  • Jinzhi He

    (University of Southern California)

  • Mingyi Zhang

    (University of Southern California)

  • Jian-Fu Chen

    (University of Southern California)

  • Yang Chai

    (University of Southern California)

Abstract

Mesenchymal stem cells (MSCs) reside in microenvironments, referred to as niches, which provide structural support and molecular signals. Sensory nerves are niche components in the homeostasis of tissues such as skin, bone marrow and hematopoietic system. However, how the sensory nerve affects the behavior of MSCs remains largely unknown. Here we show that the sensory nerve is vital for mesenchymal tissue homeostasis and maintenance of MSCs in the continuously growing adult mouse incisor. Loss of sensory innervation leads to mesenchymal disorder and a decrease in MSCs. Mechanistically, FGF1 from the sensory nerve directly acts on MSCs by binding to FGFR1 and activates the mTOR/autophagy axis to sustain MSCs. Modulation of mTOR/autophagy restores the MSCs and rescues the mesenchymal tissue disorder of Fgfr1 mutant mice. Collectively, our study provides insights into the role of sensory nerves in the regulation of MSC homeostasis and the mechanism governing it.

Suggested Citation

  • Fei Pei & Li Ma & Junjun Jing & Jifan Feng & Yuan Yuan & Tingwei Guo & Xia Han & Thach-Vu Ho & Jie Lei & Jinzhi He & Mingyi Zhang & Jian-Fu Chen & Yang Chai, 2023. "Sensory nerve niche regulates mesenchymal stem cell homeostasis via FGF/mTOR/autophagy axis," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-35977-4
    DOI: 10.1038/s41467-023-35977-4
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    1. Mingyi Zhang & Tingwei Guo & Fei Pei & Jifan Feng & Junjun Jing & Jian Xu & Takahiko Yamada & Thach-Vu Ho & Jiahui Du & Prerna Sehgal & Yang Chai, 2024. "ARID1B maintains mesenchymal stem cell quiescence via inhibition of BCL11B-mediated non-canonical Activin signaling," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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