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Sema3A regulates bone-mass accrual through sensory innervations

Author

Listed:
  • Toru Fukuda

    (School of Medicine, Keio University, Shinanomachi 35, Shinjyuku-ku, Tokyo 160-8582, Japan)

  • Shu Takeda

    (School of Medicine, Keio University, Shinanomachi 35, Shinjyuku-ku, Tokyo 160-8582, Japan)

  • Ren Xu

    (Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo-ku, Tokyo 113-8549, Japan
    Global Center of Excellence (GCOE) Program, International Research Center for Molecular Science in Tooth and Bone Diseases, Yushima 1-5-45, Bunkyo-ku, Tokyo 113-8549, Japan)

  • Hiroki Ochi

    (School of Medicine, Keio University, Shinanomachi 35, Shinjyuku-ku, Tokyo 160-8582, Japan)

  • Satoko Sunamura

    (School of Medicine, Keio University, Shinanomachi 35, Shinjyuku-ku, Tokyo 160-8582, Japan)

  • Tsuyoshi Sato

    (Saitama Medical University, Morohongo 38, Moroyama-machi, Iruma-gun, Saitama 350-0495, Japan)

  • Shinsuke Shibata

    (School of Medicine, Keio University, Shinanomachi 35, Shinjyuku-ku, Tokyo 160-8582, Japan)

  • Yutaka Yoshida

    (Cincinnati Children's Hospital Medical Center)

  • Zirong Gu

    (Cincinnati Children's Hospital Medical Center)

  • Ayako Kimura

    (Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo-ku, Tokyo 113-8549, Japan
    Hard Tissue Genome Research Center, Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo-ku, Tokyo 113-8549, Japan)

  • Chengshan Ma

    (Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo-ku, Tokyo 113-8549, Japan
    Global Center of Excellence (GCOE) Program, International Research Center for Molecular Science in Tooth and Bone Diseases, Yushima 1-5-45, Bunkyo-ku, Tokyo 113-8549, Japan)

  • Cheng Xu

    (Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo-ku, Tokyo 113-8549, Japan
    Global Center of Excellence (GCOE) Program, International Research Center for Molecular Science in Tooth and Bone Diseases, Yushima 1-5-45, Bunkyo-ku, Tokyo 113-8549, Japan)

  • Waka Bando

    (Section of Nephrology, Endocrinology and Metabolism, School of Medicine, Keio University, Shinanomachi 35, Shinjyuku-ku, Tokyo 160-8582, Japan)

  • Koji Fujita

    (Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo-ku, Tokyo 113-8549, Japan
    Global Center of Excellence (GCOE) Program, International Research Center for Molecular Science in Tooth and Bone Diseases, Yushima 1-5-45, Bunkyo-ku, Tokyo 113-8549, Japan)

  • Kenichi Shinomiya

    (Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo-ku, Tokyo 113-8549, Japan)

  • Takashi Hirai

    (Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo-ku, Tokyo 113-8549, Japan)

  • Yoshinori Asou

    (Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo-ku, Tokyo 113-8549, Japan)

  • Mitsuhiro Enomoto

    (Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo-ku, Tokyo 113-8549, Japan)

  • Hideyuki Okano

    (School of Medicine, Keio University, Shinanomachi 35, Shinjyuku-ku, Tokyo 160-8582, Japan)

  • Atsushi Okawa

    (Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo-ku, Tokyo 113-8549, Japan
    Global Center of Excellence (GCOE) Program, International Research Center for Molecular Science in Tooth and Bone Diseases, Yushima 1-5-45, Bunkyo-ku, Tokyo 113-8549, Japan)

  • Hiroshi Itoh

    (Section of Nephrology, Endocrinology and Metabolism, School of Medicine, Keio University, Shinanomachi 35, Shinjyuku-ku, Tokyo 160-8582, Japan)

Abstract

Sema3A, a member of the semaphorin family of proteins, is shown to regulate bone remodelling indirectly by modulating sensory nerve development in mice.

Suggested Citation

  • Toru Fukuda & Shu Takeda & Ren Xu & Hiroki Ochi & Satoko Sunamura & Tsuyoshi Sato & Shinsuke Shibata & Yutaka Yoshida & Zirong Gu & Ayako Kimura & Chengshan Ma & Cheng Xu & Waka Bando & Koji Fujita & , 2013. "Sema3A regulates bone-mass accrual through sensory innervations," Nature, Nature, vol. 497(7450), pages 490-493, May.
    • Handle: RePEc:nat:nature:v:497:y:2013:i:7450:d:10.1038_nature12115
    DOI: 10.1038/nature12115
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    Cited by:

    1. Lijun Wang & Xiuling You & Dengfeng Ruan & Rui Shao & Hai-Qiang Dai & Weiliang Shen & Guo-Liang Xu & Wanlu Liu & Weiguo Zou, 2022. "TET enzymes regulate skeletal development through increasing chromatin accessibility of RUNX2 target genes," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    2. Fei Pei & Li Ma & Junjun Jing & Jifan Feng & Yuan Yuan & Tingwei Guo & Xia Han & Thach-Vu Ho & Jie Lei & Jinzhi He & Mingyi Zhang & Jian-Fu Chen & Yang Chai, 2023. "Sensory nerve niche regulates mesenchymal stem cell homeostasis via FGF/mTOR/autophagy axis," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

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