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Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer

Author

Listed:
  • Jae Myoung Suh

    (Gene Expression Laboratory, Salk Institute for Biological Studies)

  • Johan W. Jonker

    (Center for Liver, Digestive and Metabolic Diseases, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands)

  • Maryam Ahmadian

    (Gene Expression Laboratory, Salk Institute for Biological Studies)

  • Regina Goetz

    (New York University School of Medicine)

  • Denise Lackey

    (University of California at San Diego)

  • Olivia Osborn

    (University of California at San Diego)

  • Zhifeng Huang

    (New York University School of Medicine
    Present address: School of Pharmacy, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.)

  • Weilin Liu

    (Center for Liver, Digestive and Metabolic Diseases, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands)

  • Eiji Yoshihara

    (Gene Expression Laboratory, Salk Institute for Biological Studies)

  • Theo H. van Dijk

    (Center for Liver, Digestive and Metabolic Diseases, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands)

  • Rick Havinga

    (Center for Liver, Digestive and Metabolic Diseases, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands)

  • Weiwei Fan

    (Gene Expression Laboratory, Salk Institute for Biological Studies)

  • Yun-Qiang Yin

    (Gene Expression Laboratory, Salk Institute for Biological Studies)

  • Ruth T. Yu

    (Gene Expression Laboratory, Salk Institute for Biological Studies)

  • Christopher Liddle

    (The Storr Liver Unit, Westmead Millennium Institute and University of Sydney, Westmead Hospital)

  • Annette R. Atkins

    (Gene Expression Laboratory, Salk Institute for Biological Studies)

  • Jerrold M. Olefsky

    (University of California at San Diego)

  • Moosa Mohammadi

    (New York University School of Medicine)

  • Michael Downes

    (Gene Expression Laboratory, Salk Institute for Biological Studies)

  • Ronald M. Evans

    (Gene Expression Laboratory, Salk Institute for Biological Studies
    Howard Hughes Medical Institute, Salk Institute for Biological Studies)

Abstract

Pharmacological fibroblast growth factor 1 (FGF1) normalizes blood glucose in diabetic mice by means of an FGF receptor signalling pathway that is independent of its mitogenic activity.

Suggested Citation

  • Jae Myoung Suh & Johan W. Jonker & Maryam Ahmadian & Regina Goetz & Denise Lackey & Olivia Osborn & Zhifeng Huang & Weilin Liu & Eiji Yoshihara & Theo H. van Dijk & Rick Havinga & Weiwei Fan & Yun-Qia, 2014. "Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer," Nature, Nature, vol. 513(7518), pages 436-439, September.
    • Handle: RePEc:nat:nature:v:513:y:2014:i:7518:d:10.1038_nature13540
    DOI: 10.1038/nature13540
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    Cited by:

    1. Lei Ying & Luyao Wang & Kaiwen Guo & Yushu Hou & Na Li & Shuyi Wang & Xingfeng Liu & Qijin Zhao & Jie Zhou & Longwei Zhao & Jianlou Niu & Chuchu Chen & Lintao Song & Shaocong Hou & Lijuan Kong & Xiaok, 2021. "Paracrine FGFs target skeletal muscle to exert potent anti-hyperglycemic effects," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    2. Fei Pei & Li Ma & Junjun Jing & Jifan Feng & Yuan Yuan & Tingwei Guo & Xia Han & Thach-Vu Ho & Jie Lei & Jinzhi He & Mingyi Zhang & Jian-Fu Chen & Yang Chai, 2023. "Sensory nerve niche regulates mesenchymal stem cell homeostasis via FGF/mTOR/autophagy axis," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

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