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Heat-inactivated Bifidobacterium adolescentis ameliorates colon senescence through Paneth-like-cell-mediated stem cell activation

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  • Yadong Qi

    (Zhejiang University School of Medicine
    Zhejiang University)

  • Jiamin He

    (Zhejiang University School of Medicine
    Zhejiang University)

  • Yawen Zhang

    (Zhejiang University School of Medicine
    Zhejiang University
    Zhejiang University School of Medicine)

  • Qiwei Ge

    (Zhejiang University
    Second Affiliated Hospital of Zhejiang University School of Medicine)

  • Qiwen Wang

    (Zhejiang University School of Medicine
    Zhejiang University)

  • Luyi Chen

    (Zhejiang University School of Medicine
    Zhejiang University School of Medicine)

  • Jilei Xu

    (Zhejiang University School of Medicine
    Zhejiang University)

  • Lan Wang

    (Zhejiang University School of Medicine
    Zhejiang University)

  • Xueqin Chen

    (Zhejiang University School of Medicine
    Zhejiang University)

  • Dingjiacheng Jia

    (Zhejiang University
    Second Affiliated Hospital of Zhejiang University School of Medicine)

  • Yifeng Lin

    (Zhejiang University
    Second Affiliated Hospital of Zhejiang University School of Medicine)

  • Chaochao Xu

    (Zhejiang University
    Second Affiliated Hospital of Zhejiang University School of Medicine)

  • Ying Zhang

    (Zhejiang University
    Second Affiliated Hospital of Zhejiang University School of Medicine)

  • Tongyao Hou

    (Zhejiang University School of Medicine
    Zhejiang University)

  • Jianmin Si

    (Zhejiang University School of Medicine
    Zhejiang University
    Zhejiang University School of Medicine)

  • Shujie Chen

    (Zhejiang University School of Medicine
    Zhejiang University
    Zhejiang University School of Medicine)

  • Liangjing Wang

    (Zhejiang University
    Zhejiang University School of Medicine
    Second Affiliated Hospital of Zhejiang University School of Medicine)

Abstract

Declined numbers and weakened functions of intestinal stem cells (ISCs) impair the integrity of the intestinal epithelium during aging. However, the impact of intestinal microbiota on ISCs in this process is unclear. Here, using premature aging mice (telomerase RNA component knockout, Terc−/−), natural aging mice, and in vitro colonoid models, we explore how heat-inactivated Bifidobacterium adolescentis (B. adolescentis) affects colon senescence. We find that B. adolescentis could mitigate colonic senescence-related changes by enhancing intestinal integrity and stimulating the regeneration of Lgr5+ ISCs via Wnt/β-catenin signaling. Furthermore, we uncover the involvement of Paneth-like cells (PLCs) within the colonic stem-cell-supporting niche in the B. adolescentis-induced ISC regeneration. In addition, we identify soluble polysaccharides (SPS) as potential effective components of B. adolescentis. Overall, our findings reveal the role of heat-inactivated B. adolescentis in maintaining the ISCs regeneration and intestinal barrier, and propose a microbiota target for ameliorating colon senescence.

Suggested Citation

  • Yadong Qi & Jiamin He & Yawen Zhang & Qiwei Ge & Qiwen Wang & Luyi Chen & Jilei Xu & Lan Wang & Xueqin Chen & Dingjiacheng Jia & Yifeng Lin & Chaochao Xu & Ying Zhang & Tongyao Hou & Jianmin Si & Shuj, 2023. "Heat-inactivated Bifidobacterium adolescentis ameliorates colon senescence through Paneth-like-cell-mediated stem cell activation," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-41827-0
    DOI: 10.1038/s41467-023-41827-0
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