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The stem-cell niche as an entity of action

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  • David T. Scadden

    (Massachusetts General Hospital Center for Regenerative Medicine, Harvard Stem Cell Institute)

Abstract

Listen to an interview with David Scadden on the stem cells podcast Stem-cell populations are established in ‘niches’ — specific anatomic locations that regulate how they participate in tissue generation, maintenance and repair. The niche saves stem cells from depletion, while protecting the host from over-exuberant stem-cell proliferation. It constitutes a basic unit of tissue physiology, integrating signals that mediate the balanced response of stem cells to the needs of organisms. Yet the niche may also induce pathologies by imposing aberrant function on stem cells or other targets. The interplay between stem cells and their niche creates the dynamic system necessary for sustaining tissues, and for the ultimate design of stem-cell therapeutics.

Suggested Citation

  • David T. Scadden, 2006. "The stem-cell niche as an entity of action," Nature, Nature, vol. 441(7097), pages 1075-1079, June.
    • Handle: RePEc:nat:nature:v:441:y:2006:i:7097:d:10.1038_nature04957
    DOI: 10.1038/nature04957
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    Cited by:

    1. Farshad Babaeijandaghi & Nasim Kajabadi & Reece Long & Lin Wei Tung & Chun Wai Cheung & Morten Ritso & Chih-Kai Chang & Ryan Cheng & Tiffany Huang & Elena Groppa & Jean X. Jiang & Fabio M. V. Rossi, 2023. "DPPIV+ fibro-adipogenic progenitors form the niche of adult skeletal muscle self-renewing resident macrophages," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    2. Zhdanov, Vladimir P., 2008. "Simulation of proliferation and differentiation of cells in a stem-cell niche," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 387(24), pages 6126-6136.
    3. Zhdanov, Vladimir P., 2009. "Signal propagation in stem-cell niches," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 388(18), pages 3791-3797.
    4. Fei Pei & Li Ma & Junjun Jing & Jifan Feng & Yuan Yuan & Tingwei Guo & Xia Han & Thach-Vu Ho & Jie Lei & Jinzhi He & Mingyi Zhang & Jian-Fu Chen & Yang Chai, 2023. "Sensory nerve niche regulates mesenchymal stem cell homeostasis via FGF/mTOR/autophagy axis," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

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