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Nr6a1 controls Hox expression dynamics and is a master regulator of vertebrate trunk development

Author

Listed:
  • Yi-Cheng Chang

    (Monash University
    Monash University)

  • Jan Manent

    (Monash University
    Monash University)

  • Jan Schroeder

    (Monash University
    Monash University
    Monash Biomedicine Discovery Institute)

  • Siew Fen Lisa Wong

    (Monash University
    Monash University)

  • Gabriel M. Hauswirth

    (Monash University
    Monash University)

  • Natalia A. Shylo

    (Stowers Institute for Medical Research)

  • Emma L. Moore

    (Stowers Institute for Medical Research)

  • Annita Achilleos

    (Stowers Institute for Medical Research
    University of Nicosia)

  • Victoria Garside

    (Monash University
    Monash University)

  • Jose M. Polo

    (Monash University
    Monash University
    Monash Biomedicine Discovery Institute)

  • Paul Trainor

    (Stowers Institute for Medical Research
    University of Kansas Medical Center)

  • Edwina McGlinn

    (Monash University
    Monash University)

Abstract

The vertebrate main-body axis is laid down during embryonic stages in an anterior-to-posterior (head-to-tail) direction, driven and supplied by posteriorly located progenitors. Whilst posterior expansion and segmentation appears broadly uniform along the axis, there is developmental and evolutionary support for at least two discrete modules controlling processes within different axial regions: a trunk and a tail module. Here, we identify Nuclear receptor subfamily 6 group A member 1 (Nr6a1) as a master regulator of trunk development in the mouse. Specifically, Nr6a1 was found to control vertebral number and segmentation of the trunk region, autonomously from other axial regions. Moreover, Nr6a1 was essential for the timely progression of Hox signatures, and neural versus mesodermal cell fate choice, within axial progenitors. Collectively, Nr6a1 has an axially-restricted role in all major cellular and tissue-level events required for vertebral column formation, supporting the view that changes in Nr6a1 levels may underlie evolutionary changes in axial formulae.

Suggested Citation

  • Yi-Cheng Chang & Jan Manent & Jan Schroeder & Siew Fen Lisa Wong & Gabriel M. Hauswirth & Natalia A. Shylo & Emma L. Moore & Annita Achilleos & Victoria Garside & Jose M. Polo & Paul Trainor & Edwina , 2022. "Nr6a1 controls Hox expression dynamics and is a master regulator of vertebrate trunk development," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-35303-4
    DOI: 10.1038/s41467-022-35303-4
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