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Biomarker correlates with response to NY-ESO-1 TCR T cells in patients with synovial sarcoma

Author

Listed:
  • Alexandra Gyurdieva

    (GlaxoSmithKline)

  • Stefan Zajic

    (GlaxoSmithKline)

  • Ya-Fang Chang

    (GlaxoSmithKline)

  • E. Andres Houseman

    (GlaxoSmithKline)

  • Shan Zhong

    (GlaxoSmithKline)

  • Jaegil Kim

    (GlaxoSmithKline)

  • Michael Nathenson

    (GlaxoSmithKline)

  • Thomas Faitg

    (GlaxoSmithKline)

  • Mary Woessner

    (GlaxoSmithKline)

  • David C. Turner

    (GlaxoSmithKline)

  • Aisha N. Hasan

    (GlaxoSmithKline)

  • John Glod

    (National Cancer Institute)

  • Rosandra N. Kaplan

    (National Cancer Institute)

  • Sandra P. D’Angelo

    (Memorial Sloan Kettering Cancer Center
    Weill Cornell Medical Center)

  • Dejka M. Araujo

    (University of Texas/MD Anderson Cancer Center)

  • Warren A. Chow

    (City of Hope Comprehensive Cancer Center)

  • Mihaela Druta

    (H. Lee Moffitt Cancer Center)

  • George D. Demetri

    (Dana-Farber Cancer Institute and Ludwig Center at Harvard)

  • Brian A. Tine

    (Washington University in St. Louis School of Medicine)

  • Stephan A. Grupp

    (Children’s Hospital of Philadelphia and University of Pennsylvania)

  • Gregg D. Fine

    (GlaxoSmithKline)

  • Ioanna Eleftheriadou

    (GlaxoSmithKline)

Abstract

Autologous T cells transduced to express a high affinity T-cell receptor specific to NY-ESO-1 (letetresgene autoleucel, lete-cel) show promise in the treatment of metastatic synovial sarcoma, with 50% overall response rate. The efficacy of lete-cel treatment in 45 synovial sarcoma patients (NCT01343043) has been previously reported, however, biomarkers predictive of response and resistance remain to be better defined. This post-hoc analysis identifies associations of response to lete-cel with lymphodepleting chemotherapy regimen (LDR), product attributes, cell expansion, cytokines, and tumor gene expression. Responders have higher IL-15 levels pre-infusion (p = 0.011) and receive a higher number of transduced effector memory (CD45RA- CCR7-) CD8 + cells per kg (p = 0.039). Post-infusion, responders have increased IFNγ, IL-6, and peak cell expansion (p

Suggested Citation

  • Alexandra Gyurdieva & Stefan Zajic & Ya-Fang Chang & E. Andres Houseman & Shan Zhong & Jaegil Kim & Michael Nathenson & Thomas Faitg & Mary Woessner & David C. Turner & Aisha N. Hasan & John Glod & Ro, 2022. "Biomarker correlates with response to NY-ESO-1 TCR T cells in patients with synovial sarcoma," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-32491-x
    DOI: 10.1038/s41467-022-32491-x
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    References listed on IDEAS

    as
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