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Evolution of Hoxa11 regulation in vertebrates is linked to the pentadactyl state

Author

Listed:
  • Yacine Kherdjemil

    (Genetics and Development Research Unit, Institut de Recherches Cliniques de Montréal
    Université de Montréal)

  • Robert L. Lalonde

    (University of Ottawa)

  • Rushikesh Sheth

    (Genetics and Development Research Unit, Institut de Recherches Cliniques de Montréal)

  • Annie Dumouchel

    (Genetics and Development Research Unit, Institut de Recherches Cliniques de Montréal)

  • Gemma de Martino

    (Genetics and Development Research Unit, Institut de Recherches Cliniques de Montréal
    †Present address: Department of Biology, McGill University, Montreal, Quebec H3A 1B1, Canada.)

  • Kyriel M. Pineault

    (University of Michigan)

  • Deneen M. Wellik

    (University of Michigan)

  • H. Scott Stadler

    (Shriners Hospital for Children)

  • Marie-Andrée Akimenko

    (University of Ottawa)

  • Marie Kmita

    (Genetics and Development Research Unit, Institut de Recherches Cliniques de Montréal
    Université de Montréal
    McGill University)

Abstract

The mutually exclusive expression of the Hoxa11 and Hoxa13 genes is required for pentadactyl (five-digit) limbs and is proposed to have contributed to the transition from several digits polydactyl (several-digit) limbs in the earliest tetrapods.

Suggested Citation

  • Yacine Kherdjemil & Robert L. Lalonde & Rushikesh Sheth & Annie Dumouchel & Gemma de Martino & Kyriel M. Pineault & Deneen M. Wellik & H. Scott Stadler & Marie-Andrée Akimenko & Marie Kmita, 2016. "Evolution of Hoxa11 regulation in vertebrates is linked to the pentadactyl state," Nature, Nature, vol. 539(7627), pages 89-92, November.
    • Handle: RePEc:nat:nature:v:539:y:2016:i:7627:d:10.1038_nature19813
    DOI: 10.1038/nature19813
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    Cited by:

    1. Aiko Kawasumi-Kita & Sang-Woo Lee & Daisuke Ohtsuka & Kaori Niimi & Yoshifumi Asakura & Keiichi Kitajima & Yuto Sakane & Koji Tamura & Haruki Ochi & Ken-ichi T. Suzuki & Yoshihiro Morishita, 2024. "hoxc12/c13 as key regulators for rebooting the developmental program in Xenopus limb regeneration," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    2. Yi-Cheng Chang & Jan Manent & Jan Schroeder & Siew Fen Lisa Wong & Gabriel M. Hauswirth & Natalia A. Shylo & Emma L. Moore & Annita Achilleos & Victoria Garside & Jose M. Polo & Paul Trainor & Edwina , 2022. "Nr6a1 controls Hox expression dynamics and is a master regulator of vertebrate trunk development," Nature Communications, Nature, vol. 13(1), pages 1-19, December.

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