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Mitochondrial Fission Process 1 controls inner membrane integrity and protects against heart failure

Author

Listed:
  • Erminia Donnarumma

    (Université Paris Cité)

  • Michael Kohlhaas

    (University Clinic Würzburg)

  • Elodie Vimont

    (Université Paris Cité)

  • Etienne Kornobis

    (Université Paris Cité
    Université Paris Cité)

  • Thibault Chaze

    (Université Paris Cité)

  • Quentin Giai Gianetto

    (Université Paris Cité
    Université Paris Cité)

  • Mariette Matondo

    (Université Paris Cité)

  • Maryse Moya-Nilges

    (UTechS, Université Paris Cité)

  • Christoph Maack

    (University Clinic Würzburg)

  • Timothy Wai

    (Université Paris Cité)

Abstract

Mitochondria are paramount to the metabolism and survival of cardiomyocytes. Here we show that Mitochondrial Fission Process 1 (MTFP1) is an inner mitochondrial membrane (IMM) protein that is dispensable for mitochondrial division yet essential for cardiac structure and function. Constitutive knockout of cardiomyocyte MTFP1 in mice resulted in a fatal, adult-onset dilated cardiomyopathy accompanied by extensive mitochondrial and cardiac remodeling during the transition to heart failure. Prior to the onset of disease, knockout cardiac mitochondria displayed specific IMM defects: futile proton leak dependent upon the adenine nucleotide translocase and an increased sensitivity to the opening of the mitochondrial permeability transition pore, with which MTFP1 physically and genetically interacts. Collectively, our data reveal new functions of MTFP1 in the control of bioenergetic efficiency and cell death sensitivity and define its importance in preventing pathogenic cardiac remodeling.

Suggested Citation

  • Erminia Donnarumma & Michael Kohlhaas & Elodie Vimont & Etienne Kornobis & Thibault Chaze & Quentin Giai Gianetto & Mariette Matondo & Maryse Moya-Nilges & Christoph Maack & Timothy Wai, 2022. "Mitochondrial Fission Process 1 controls inner membrane integrity and protects against heart failure," Nature Communications, Nature, vol. 13(1), pages 1-24, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-34316-3
    DOI: 10.1038/s41467-022-34316-3
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    1. Masaki Takasugi & Yoshiki Nonaka & Kazuaki Takemura & Yuya Yoshida & Frank Stein & Jennifer J. Schwarz & Jun Adachi & Junko Satoh & Shinji Ito & Gregory Tombline & Seyed Ali Biashad & Andrei Seluanov , 2024. "An atlas of the aging mouse proteome reveals the features of age-related post-transcriptional dysregulation," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    2. Cecilia Patitucci & Juan Diego Hernández-Camacho & Elodie Vimont & Sonny Yde & Thomas Cokelaer & Thibault Chaze & Quentin Giai Gianetto & Mariette Matondo & Anastasia Gazi & Ivan Nemazanyy & David A. , 2023. "Mtfp1 ablation enhances mitochondrial respiration and protects against hepatic steatosis," Nature Communications, Nature, vol. 14(1), pages 1-21, December.

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