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Tbx6-dependent Sox2 regulation determines neural or mesodermal fate in axial stem cells

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  • Tatsuya Takemoto

    (Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamadaoka, Suita, Osaka 565-0871, Japan)

  • Masanori Uchikawa

    (Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamadaoka, Suita, Osaka 565-0871, Japan)

  • Megumi Yoshida

    (Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamadaoka, Suita, Osaka 565-0871, Japan)

  • Donald M. Bell

    (MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK)

  • Robin Lovell-Badge

    (MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK)

  • Virginia E. Papaioannou

    (College of Physicians and Surgeons of Columbia University, 701 West 168th Street, New York, New York 10032, USA)

  • Hisato Kondoh

    (Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamadaoka, Suita, Osaka 565-0871, Japan)

Abstract

Cell fate in the early embryo A population of axial stem cells present in the caudal lateral epiblast of the mouse embryo is known to produce both neural plate and mesoderm cells, but the factors regulating this choice are unknown. Takemoto et al. now show that Tbx6-dependent modulation of the developmental transcription factor Sox2 drives the fate of these axial stem cells. In the absence of Tbx6, cells aberrantly upregulated Sox2 activity, meaning that cells originally destined to be mesoderm turned into ectopic neural tubes. This work and recent cell-lineage analyses challenge the textbook view that segregation of the three germ layers (ectoderm, mesoderm, endoderm) is the process specifying cell lineages in early embryos. Rather, the paraxial mesoderm (producing muscle and bone) and neural plate (producing the brain and spinal cord) seem to be derived from common stem-cell-like precursors.

Suggested Citation

  • Tatsuya Takemoto & Masanori Uchikawa & Megumi Yoshida & Donald M. Bell & Robin Lovell-Badge & Virginia E. Papaioannou & Hisato Kondoh, 2011. "Tbx6-dependent Sox2 regulation determines neural or mesodermal fate in axial stem cells," Nature, Nature, vol. 470(7334), pages 394-398, February.
    • Handle: RePEc:nat:nature:v:470:y:2011:i:7334:d:10.1038_nature09729
    DOI: 10.1038/nature09729
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    Cited by:

    1. Yi-Cheng Chang & Jan Manent & Jan Schroeder & Siew Fen Lisa Wong & Gabriel M. Hauswirth & Natalia A. Shylo & Emma L. Moore & Annita Achilleos & Victoria Garside & Jose M. Polo & Paul Trainor & Edwina , 2022. "Nr6a1 controls Hox expression dynamics and is a master regulator of vertebrate trunk development," Nature Communications, Nature, vol. 13(1), pages 1-19, December.

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