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Every-other-day feeding extends lifespan but fails to delay many symptoms of aging in mice

Author

Listed:
  • Kan Xie

    (German Center for Neurodegenerative Diseases)

  • Frauke Neff

    (German Research Center for Environmental Health
    German Research Center for Environmental Health)

  • Astrid Markert

    (German Center for Neurodegenerative Diseases)

  • Jan Rozman

    (German Research Center for Environmental Health
    Member of German Center for Diabetes Research (DZD))

  • Juan Antonio Aguilar-Pimentel

    (German Research Center for Environmental Health
    Technische Universität München/Helmholtz Zentrum München)

  • Oana Veronica Amarie

    (German Research Center for Environmental Health
    German Research Center for Environmental Health)

  • Lore Becker

    (German Research Center for Environmental Health)

  • Robert Brommage

    (German Research Center for Environmental Health)

  • Lillian Garrett

    (German Research Center for Environmental Health
    German Research Center for Environmental Health)

  • Kristin S. Henzel

    (German Center for Neurodegenerative Diseases)

  • Sabine M. Hölter

    (German Research Center for Environmental Health
    German Research Center for Environmental Health)

  • Dirk Janik

    (German Research Center for Environmental Health
    German Research Center for Environmental Health)

  • Isabelle Lehmann

    (German Center for Neurodegenerative Diseases)

  • Kristin Moreth

    (German Research Center for Environmental Health)

  • Brandon L. Pearson

    (German Center for Neurodegenerative Diseases)

  • Ildiko Racz

    (German Research Center for Environmental Health
    University of Bonn)

  • Birgit Rathkolb

    (German Research Center for Environmental Health
    Member of German Center for Diabetes Research (DZD)
    Ludwig-Maximilians-Universität München)

  • Devon P. Ryan

    (German Center for Neurodegenerative Diseases)

  • Susanne Schröder

    (German Center for Neurodegenerative Diseases)

  • Irina Treise

    (German Research Center for Environmental Health
    Technische Universität München)

  • Raffi Bekeredjian

    (University of Heidelberg)

  • Dirk H. Busch

    (Technische Universität München)

  • Jochen Graw

    (German Research Center for Environmental Health)

  • Gerhard Ehninger

    (University Hospital Carl Gustav Carus, Technical University Dresden)

  • Martin Klingenspor

    (Technische Universität München)

  • Thomas Klopstock

    (Ludwig-Maximilians-Universität München
    University Hospital Munich, Campus Grosshadern
    German Center for Neurodegenerative Diseases
    Munich Cluster for Systems Neurology (SyNergy))

  • Markus Ollert

    (Luxembourg Institute of Health
    University of Southern Denmark)

  • Michael Sandholzer

    (German Research Center for Environmental Health
    German Research Center for Environmental Health)

  • Carsten Schmidt-Weber

    (Technische Universität München and Helmholtz Zentrum München
    Member of the German Center for Lung Research (DZL))

  • Marco Weiergräber

    (Federal Institute for Drugs and Medical Devices)

  • Eckhard Wolf

    (Ludwig-Maximilians-Universität München)

  • Wolfgang Wurst

    (German Research Center for Environmental Health
    German Center for Neurodegenerative Diseases
    Munich Cluster for Systems Neurology (SyNergy)
    Technische Universität München, c/o Helmholtz Zentrum München, German Research Center for Environmental Health)

  • Andreas Zimmer

    (University of Bonn)

  • Valerie Gailus-Durner

    (German Research Center for Environmental Health)

  • Helmut Fuchs

    (German Research Center for Environmental Health)

  • Martin Hrabě de Angelis

    (German Research Center for Environmental Health
    Member of German Center for Diabetes Research (DZD)
    Technische Universität München)

  • Dan Ehninger

    (German Center for Neurodegenerative Diseases)

Abstract

Dietary restriction regimes extend lifespan in various animal models. Here we show that longevity in male C57BL/6J mice subjected to every-other-day feeding is associated with a delayed onset of neoplastic disease that naturally limits lifespan in these animals. We compare more than 200 phenotypes in over 20 tissues in aged animals fed with a lifelong every-other-day feeding or ad libitum access to food diet to determine whether molecular, cellular, physiological and histopathological aging features develop more slowly in every-other-day feeding mice than in controls. We also analyze the effects of every-other-day feeding on young mice on shorter-term every-other-day feeding or ad libitum to account for possible aging-independent restriction effects. Our large-scale analysis reveals overall only limited evidence for a retardation of the aging rate in every-other-day feeding mice. The data indicate that every-other-day feeding-induced longevity is sufficiently explained by delays in life-limiting neoplastic disorders and is not associated with a more general slowing of the aging process in mice.

Suggested Citation

  • Kan Xie & Frauke Neff & Astrid Markert & Jan Rozman & Juan Antonio Aguilar-Pimentel & Oana Veronica Amarie & Lore Becker & Robert Brommage & Lillian Garrett & Kristin S. Henzel & Sabine M. Hölter & Di, 2017. "Every-other-day feeding extends lifespan but fails to delay many symptoms of aging in mice," Nature Communications, Nature, vol. 8(1), pages 1-19, December.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-00178-3
    DOI: 10.1038/s41467-017-00178-3
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    Cited by:

    1. Kan Xie & Helmut Fuchs & Enzo Scifo & Dan Liu & Ahmad Aziz & Juan Antonio Aguilar-Pimentel & Oana Veronica Amarie & Lore Becker & Patricia da Silva-Buttkus & Julia Calzada-Wack & Yi-Li Cho & Yushuang , 2022. "Deep phenotyping and lifetime trajectories reveal limited effects of longevity regulators on the aging process in C57BL/6J mice," Nature Communications, Nature, vol. 13(1), pages 1-29, December.

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