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C. elegans maximum velocity correlates with healthspan and is maintained in worms with an insulin receptor mutation

Author

Listed:
  • Jeong-Hoon Hahm

    (Center for Plant Aging Research, Institute for Basic Science)

  • Sunhee Kim

    (Center for Plant Aging Research, Institute for Basic Science)

  • Race DiLoreto

    (Lewis-Sigler Institute for Integrative Genomics, Princeton University)

  • Cheng Shi

    (Lewis-Sigler Institute for Integrative Genomics, Princeton University)

  • Seung-Jae V. Lee

    (Pohang University of Science and Technology)

  • Coleen T. Murphy

    (Lewis-Sigler Institute for Integrative Genomics, Princeton University)

  • Hong Gil Nam

    (Center for Plant Aging Research, Institute for Basic Science
    DGIST)

Abstract

Ageing is marked by physical decline. Caenorhabditis elegans is a valuable model for identifying genetic regulatory mechanisms of ageing and longevity. Here we report a simple method to assess C. elegans’ maximum physical ability based on the worms’ maximum movement velocity. We show maximum velocity declines with age, correlates well with longevity, accurately reports movement ability and, if measured in mid-adulthood, is predictive of maximal lifespan. Contrary to recent findings, we observe that maximum velocity of worm with mutations in daf-2(e1370) insulin/IGF-1 signalling scales with lifespan. Because of increased odorant receptor expression, daf-2(e1370) mutants prefer food over exploration, causing previous on-food motility assays to underestimate movement ability and, thus, worm health. Finally, a disease-burden analysis of published data reveals that the daf-2(e1370) mutation improves quality of life, and therefore combines lifespan extension with various signs of an increased healthspan.

Suggested Citation

  • Jeong-Hoon Hahm & Sunhee Kim & Race DiLoreto & Cheng Shi & Seung-Jae V. Lee & Coleen T. Murphy & Hong Gil Nam, 2015. "C. elegans maximum velocity correlates with healthspan and is maintained in worms with an insulin receptor mutation," Nature Communications, Nature, vol. 6(1), pages 1-7, December.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms9919
    DOI: 10.1038/ncomms9919
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    Cited by:

    1. Kan Xie & Helmut Fuchs & Enzo Scifo & Dan Liu & Ahmad Aziz & Juan Antonio Aguilar-Pimentel & Oana Veronica Amarie & Lore Becker & Patricia da Silva-Buttkus & Julia Calzada-Wack & Yi-Li Cho & Yushuang , 2022. "Deep phenotyping and lifetime trajectories reveal limited effects of longevity regulators on the aging process in C57BL/6J mice," Nature Communications, Nature, vol. 13(1), pages 1-29, December.
    2. Drew Benjamin Sinha & Zachary Scott Pincus, 2022. "High temporal resolution measurements of movement reveal novel early-life physiological decline in C. elegans," PLOS ONE, Public Library of Science, vol. 17(2), pages 1-17, February.
    3. Carolin Thomas & Reto Erni & Jia Yee Wu & Fabian Fischer & Greta Lamers & Giovanna Grigolon & Sarah J. Mitchell & Kim Zarse & Erick M. Carreira & Michael Ristow, 2023. "A naturally occurring polyacetylene isolated from carrots promotes health and delays signatures of aging," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    4. Céline N Martineau & André E X Brown & Patrick Laurent, 2020. "Multidimensional phenotyping predicts lifespan and quantifies health in Caenorhabditis elegans," PLOS Computational Biology, Public Library of Science, vol. 16(7), pages 1-14, July.

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