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Inactivated vaccine-elicited potent antibodies can broadly neutralize SARS-CoV-2 circulating variants

Author

Listed:
  • Yubin Liu

    (Tsinghua University
    Shenzhen Bay Laboratory)

  • Ziyi Wang

    (Tsinghua University)

  • Xinyu Zhuang

    (Chinese Academy of Agricultural Sciences)

  • Shengnan Zhang

    (the First Affiliated Hospital of Guangzhou Medical University)

  • Zhicheng Chen

    (Center for Translational Research, Shenzhen Bay Laboratory)

  • Yan Zou

    (Shenzhen Bay Laboratory)

  • Jie Sheng

    (Shenzhen Bay Laboratory)

  • Tianpeng Li

    (Center for Translational Research, Shenzhen Bay Laboratory)

  • Wanbo Tai

    (Shenzhen Bay Laboratory)

  • Jinfang Yu

    (Tsinghua University)

  • Yanqun Wang

    (the First Affiliated Hospital of Guangzhou Medical University)

  • Zhaoyong Zhang

    (the First Affiliated Hospital of Guangzhou Medical University)

  • Yunfeng Chen

    (Shenzhen Bay Laboratory)

  • Liangqin Tong

    (Tsinghua University)

  • Xi Yu

    (Tsinghua University)

  • Linjuan Wu

    (Tsinghua University)

  • Dong Chen

    (Wenzhou Central Hospital)

  • Renli Zhang

    (Shenzhen Center for Disease Control and Prevention)

  • Ningyi Jin

    (Chinese Academy of Agricultural Sciences)

  • Weijun Shen

    (Center for Translational Research, Shenzhen Bay Laboratory)

  • Jincun Zhao

    (the First Affiliated Hospital of Guangzhou Medical University)

  • Mingyao Tian

    (Chinese Academy of Agricultural Sciences)

  • Xinquan Wang

    (Tsinghua University)

  • Gong Cheng

    (Tsinghua University
    Shenzhen Bay Laboratory)

Abstract

A full understanding of the inactivated COVID-19 vaccine-mediated antibody responses to SARS-CoV-2 circulating variants will inform vaccine effectiveness and vaccination development strategies. Here, we offer insights into the inactivated vaccine-induced antibody responses after prime-boost vaccination at both the polyclonal and monoclonal levels. We characterized the VDJ sequence of 118 monoclonal antibodies (mAbs) and found that 20 neutralizing mAbs showed varied potency and breadth against a range of variants including XBB.1.5, BQ.1.1, and BN.1. Bispecific antibodies (bsAbs) based on nonoverlapping mAbs exhibited enhanced neutralizing potency and breadth against the most antibody-evasive strains, such as XBB.1.5, BQ.1.1, and BN.1. The passive transfer of mAbs or their bsAb effectively protected female hACE2 transgenic mice from challenge with an infectious Delta or Omicron BA.2 variant. The neutralization mechanisms of these antibodies were determined by structural characterization. Overall, a broad spectrum of potent and distinct neutralizing antibodies can be induced in individuals immunized with the SARS-CoV-2 inactivated vaccine BBIBP-CorV, suggesting the application potential of inactivated vaccines and these antibodies for preventing infection by SARS-CoV-2 circulating variants.

Suggested Citation

  • Yubin Liu & Ziyi Wang & Xinyu Zhuang & Shengnan Zhang & Zhicheng Chen & Yan Zou & Jie Sheng & Tianpeng Li & Wanbo Tai & Jinfang Yu & Yanqun Wang & Zhaoyong Zhang & Yunfeng Chen & Liangqin Tong & Xi Yu, 2023. "Inactivated vaccine-elicited potent antibodies can broadly neutralize SARS-CoV-2 circulating variants," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
  • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-37926-7
    DOI: 10.1038/s41467-023-37926-7
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