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SARS-CoV-2 Omicron variant causes mild pathology in the upper and lower respiratory tract of hamsters

Author

Listed:
  • Federico Armando

    (University of Veterinary Medicine, Foundation)

  • Georg Beythien

    (University of Veterinary Medicine, Foundation)

  • Franziska K. Kaiser

    (University of Veterinary Medicine, Foundation)

  • Lisa Allnoch

    (University of Veterinary Medicine, Foundation)

  • Laura Heydemann

    (University of Veterinary Medicine, Foundation)

  • Malgorzata Rosiak

    (University of Veterinary Medicine, Foundation)

  • Svenja Becker

    (University of Veterinary Medicine, Foundation)

  • Mariana Gonzalez-Hernandez

    (University of Veterinary Medicine, Foundation)

  • Mart M. Lamers

    (Erasmus MC)

  • Bart L. Haagmans

    (Erasmus MC)

  • Kate Guilfoyle

    (Viroclinics Xplore)

  • Geert Amerongen

    (Viroclinics Xplore)

  • Malgorzata Ciurkiewicz

    (University of Veterinary Medicine, Foundation)

  • Albert D.M.E. Osterhaus

    (University of Veterinary Medicine, Foundation
    Center of Excellence, University of Veterinary Medicine, Foundation)

  • Wolfgang Baumgärtner

    (University of Veterinary Medicine, Foundation)

Abstract

Since its discovery in 2019, multiple variants of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) have been identified. This study investigates virus spread and associated pathology in the upper and lower respiratory tracts of Syrian golden hamsters at 4 days post intranasal SARS-CoV-2 Omicron infection, in comparison to infection with variants of concern (VOCs) Gamma and Delta as well as ancestral strain 614 G. Pathological changes in the upper and lower respiratory tract of VOC Omicron infected hamsters are milder than those caused by other investigated strains. VOC Omicron infection causes a mild rhinitis with little involvement of the olfactory epithelium and minimal lesions in the lung, with frequent sparing of the alveolar compartment. Similarly, viral antigen, RNA and infectious virus titers are lower in respiratory tissues of VOC Omicron infected hamsters. These findings demonstrate that the variant has a decreased pathogenicity for the upper and lower respiratory tract of hamsters.

Suggested Citation

  • Federico Armando & Georg Beythien & Franziska K. Kaiser & Lisa Allnoch & Laura Heydemann & Malgorzata Rosiak & Svenja Becker & Mariana Gonzalez-Hernandez & Mart M. Lamers & Bart L. Haagmans & Kate Gui, 2022. "SARS-CoV-2 Omicron variant causes mild pathology in the upper and lower respiratory tract of hamsters," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-31200-y
    DOI: 10.1038/s41467-022-31200-y
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    as
    1. Rigel Suzuki & Daichi Yamasoba & Izumi Kimura & Lei Wang & Mai Kishimoto & Jumpei Ito & Yuhei Morioka & Naganori Nao & Hesham Nasser & Keiya Uriu & Yusuke Kosugi & Masumi Tsuda & Yasuko Orba & Michihi, 2022. "Attenuated fusogenicity and pathogenicity of SARS-CoV-2 Omicron variant," Nature, Nature, vol. 603(7902), pages 700-705, March.
    2. Rémy Robinot & Mathieu Hubert & Guilherme Dias Melo & Françoise Lazarini & Timothée Bruel & Nikaïa Smith & Sylvain Levallois & Florence Larrous & Julien Fernandes & Stacy Gellenoncourt & Stéphane Riga, 2021. "SARS-CoV-2 infection induces the dedifferentiation of multiciliated cells and impairs mucociliary clearance," Nature Communications, Nature, vol. 12(1), pages 1-16, December.
    3. Jessica A. Plante & Yang Liu & Jianying Liu & Hongjie Xia & Bryan A. Johnson & Kumari G. Lokugamage & Xianwen Zhang & Antonio E. Muruato & Jing Zou & Camila R. Fontes-Garfias & Divya Mirchandani & Dio, 2021. "Spike mutation D614G alters SARS-CoV-2 fitness," Nature, Nature, vol. 592(7852), pages 116-121, April.
    4. Francisco J. Salguero & Andrew D. White & Gillian S. Slack & Susan A. Fotheringham & Kevin R. Bewley & Karen E. Gooch & Stephanie Longet & Holly E. Humphries & Robert J. Watson & Laura Hunter & Kathry, 2021. "Comparison of rhesus and cynomolgus macaques as an infection model for COVID-19," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    5. Peter J. Halfmann & Shun Iida & Kiyoko Iwatsuki-Horimoto & Tadashi Maemura & Maki Kiso & Suzanne M. Scheaffer & Tamarand L. Darling & Astha Joshi & Samantha Loeber & Gagandeep Singh & Stephanie L. Fos, 2022. "SARS-CoV-2 Omicron virus causes attenuated disease in mice and hamsters," Nature, Nature, vol. 603(7902), pages 687-692, March.
    6. Jessica A. Plante & Yang Liu & Jianying Liu & Hongjie Xia & Bryan A. Johnson & Kumari G. Lokugamage & Xianwen Zhang & Antonio E. Muruato & Jing Zou & Camila R. Fontes-Garfias & Divya Mirchandani & Dio, 2021. "Author Correction: Spike mutation D614G alters SARS-CoV-2 fitness," Nature, Nature, vol. 595(7865), pages 1-1, July.
    7. Sin Fun Sia & Li-Meng Yan & Alex W. H. Chin & Kevin Fung & Ka-Tim Choy & Alvina Y. L. Wong & Prathanporn Kaewpreedee & Ranawaka A. P. M. Perera & Leo L. M. Poon & John M. Nicholls & Malik Peiris & Hui, 2020. "Pathogenesis and transmission of SARS-CoV-2 in golden hamsters," Nature, Nature, vol. 583(7818), pages 834-838, July.
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    Cited by:

    1. Guilherme Dias de Melo & Victoire Perraud & Flavio Alvarez & Alba Vieites-Prado & Seonhee Kim & Lauriane Kergoat & Anthony Coleon & Bettina Salome Trüeb & Magali Tichit & Aurèle Piazza & Agnès Thierry, 2023. "Neuroinvasion and anosmia are independent phenomena upon infection with SARS-CoV-2 and its variants," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    2. Franziska K. Kaiser & Mariana Gonzalez Hernandez & Nadine Krüger & Ellinor Englund & Wenjuan Du & Anna Z. Mykytyn & Mathijs P. Raadsen & Mart M. Lamers & Francine Rodrigues Ianiski & Tatiana M. Shamor, 2024. "Filamentous fungus-produced human monoclonal antibody provides protection against SARS-CoV-2 in hamster and non-human primate models," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    3. Laura Heydemann & Małgorzata Ciurkiewicz & Georg Beythien & Kathrin Becker & Klaus Schughart & Stephanie Stanelle-Bertram & Berfin Schaumburg & Nancy Mounogou-Kouassi & Sebastian Beck & Martin Zickler, 2023. "Hamster model for post-COVID-19 alveolar regeneration offers an opportunity to understand post-acute sequelae of SARS-CoV-2," Nature Communications, Nature, vol. 14(1), pages 1-19, December.

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