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Periosteal stem cells control growth plate stem cells during postnatal skeletal growth

Author

Listed:
  • Masayuki Tsukasaki

    (The University of Tokyo)

  • Noriko Komatsu

    (The University of Tokyo)

  • Takako Negishi-Koga

    (Juntendo University Graduate School of Medicine)

  • Nam Cong-Nhat Huynh

    (The University of Tokyo
    University of Medicine and Pharmacy at Ho Chi Minh City)

  • Ryunosuke Muro

    (The University of Tokyo)

  • Yutaro Ando

    (The University of Tokyo
    Tokyo Dental College)

  • Yuka Seki

    (The University of Tokyo)

  • Asuka Terashima

    (The University of Tokyo
    The University of Tokyo Hospital)

  • Warunee Pluemsakunthai

    (The University of Tokyo)

  • Takeshi Nitta

    (The University of Tokyo)

  • Takashi Nakamura

    (Tokyo Dental College)

  • Tomoki Nakashima

    (Tokyo Medical and Dental University)

  • Shinsuke Ohba

    (Nagasaki University
    Osaka University)

  • Haruhiko Akiyama

    (Gifu University)

  • Kazuo Okamoto

    (The University of Tokyo)

  • Roland Baron

    (Harvard School of Dental Medicine
    Harvard Medical School and Endocrine Unit, MGH)

  • Hiroshi Takayanagi

    (The University of Tokyo)

Abstract

The ontogeny and fate of stem cells have been extensively investigated by lineage-tracing approaches. At distinct anatomical sites, bone tissue harbors multiple types of skeletal stem cells, which may independently supply osteogenic cells in a site-specific manner. Periosteal stem cells (PSCs) and growth plate resting zone stem cells (RZSCs) critically contribute to intramembranous and endochondral bone formation, respectively. However, it remains unclear whether there is functional crosstalk between these two types of skeletal stem cells. Here we show PSCs are not only required for intramembranous bone formation, but also for the growth plate maintenance and prolonged longitudinal bone growth. Mice deficient in PSCs display progressive defects in intramembranous and endochondral bone formation, the latter of which is caused by a deficiency in PSC-derived Indian hedgehog (Ihh). PSC-specific deletion of Ihh impairs the maintenance of the RZSCs, leading to a severe defect in endochondral bone formation in postnatal life. Thus, crosstalk between periosteal and growth plate stem cells is essential for post-developmental skeletal growth.

Suggested Citation

  • Masayuki Tsukasaki & Noriko Komatsu & Takako Negishi-Koga & Nam Cong-Nhat Huynh & Ryunosuke Muro & Yutaro Ando & Yuka Seki & Asuka Terashima & Warunee Pluemsakunthai & Takeshi Nitta & Takashi Nakamura, 2022. "Periosteal stem cells control growth plate stem cells during postnatal skeletal growth," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-31592-x
    DOI: 10.1038/s41467-022-31592-x
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    References listed on IDEAS

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