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The fate of early perichondrial cells in developing bones

Author

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  • Yuki Matsushita

    (University of Texas Health Science Center at Houston School of Dentistry
    Nagasaki University Graduate School of Biomedical Sciences)

  • Angel Ka Yan Chu

    (University of Michigan)

  • Chiaki Tsutsumi-Arai

    (University of Texas Health Science Center at Houston School of Dentistry)

  • Shion Orikasa

    (University of Texas Health Science Center at Houston School of Dentistry)

  • Mizuki Nagata

    (University of Texas Health Science Center at Houston School of Dentistry)

  • Sunny Y. Wong

    (University of Michigan Medical School)

  • Joshua D. Welch

    (University of Michigan)

  • Wanida Ono

    (University of Texas Health Science Center at Houston School of Dentistry)

  • Noriaki Ono

    (University of Texas Health Science Center at Houston School of Dentistry)

Abstract

In endochondral bone development, bone-forming osteoblasts and bone marrow stromal cells have dual origins in the fetal cartilage and its surrounding perichondrium. However, how early perichondrial cells distinctively contribute to developing bones remain unidentified. Here we show using in vivo cell-lineage analyses that Dlx5+ fetal perichondrial cells marked by Dlx5-creER do not generate cartilage but sustainably contribute to cortical bone and marrow stromal compartments in a manner complementary to fetal chondrocyte derivatives under the regulation of Hedgehog signaling. Postnatally, Dlx5+ fetal perichondrial cell derivatives preferentially populate the diaphyseal marrow stroma with a dormant adipocyte-biased state and are refractory to parathyroid hormone-induced bone anabolism. Therefore, early perichondrial cells of the fetal cartilage are destined to become an adipogenic subset of stromal cells in postnatal diaphyseal bone marrow, supporting the theory that the adult bone marrow stromal compartments are developmentally prescribed within the two distinct cells-of-origins of the fetal bone anlage.

Suggested Citation

  • Yuki Matsushita & Angel Ka Yan Chu & Chiaki Tsutsumi-Arai & Shion Orikasa & Mizuki Nagata & Sunny Y. Wong & Joshua D. Welch & Wanida Ono & Noriaki Ono, 2022. "The fate of early perichondrial cells in developing bones," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
  • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-34804-6
    DOI: 10.1038/s41467-022-34804-6
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