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Developmental regulation of the growth plate

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  • Henry M. Kronenberg

    (Endocrine Unit, Massachusetts General Hospital and Harvard Medical School)

Abstract

Vertebrates do not look like jellyfish because the bones of their skeletons are levers that allow movement and protect vital organs. Bones come in an enormous variety of shapes and sizes to accomplish these goals, but, with few exceptions, use one process — endochondral bone formation — to generate the skeleton. The past few years have seen an enormous increase in understanding of the signalling pathways and the transcription factors that control endochondral bone development.

Suggested Citation

  • Henry M. Kronenberg, 2003. "Developmental regulation of the growth plate," Nature, Nature, vol. 423(6937), pages 332-336, May.
    • Handle: RePEc:nat:nature:v:423:y:2003:i:6937:d:10.1038_nature01657
    DOI: 10.1038/nature01657
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    Cited by:

    1. Aaron Warren & Ryan M. Porter & Olivia Reyes-Castro & Md Mohsin Ali & Adriana Marques-Carvalho & Ha-Neui Kim & Landon B. Gatrell & Ernestina Schipani & Intawat Nookaew & Charles A. O’Brien & Roy Morel, 2023. "The NAD salvage pathway in mesenchymal cells is indispensable for skeletal development in mice," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    2. Marketa Kaucka & Alberto Joven Araus & Marketa Tesarova & Joshua D. Currie & Johan Boström & Michaela Kavkova & Julian Petersen & Zeyu Yao & Anass Bouchnita & Andreas Hellander & Tomas Zikmund & Ahmed, 2022. "Altered developmental programs and oriented cell divisions lead to bulky bones during salamander limb regeneration," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    3. Yuki Matsushita & Angel Ka Yan Chu & Chiaki Tsutsumi-Arai & Shion Orikasa & Mizuki Nagata & Sunny Y. Wong & Joshua D. Welch & Wanida Ono & Noriaki Ono, 2022. "The fate of early perichondrial cells in developing bones," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    4. Masayuki Tsukasaki & Noriko Komatsu & Takako Negishi-Koga & Nam Cong-Nhat Huynh & Ryunosuke Muro & Yutaro Ando & Yuka Seki & Asuka Terashima & Warunee Pluemsakunthai & Takeshi Nitta & Takashi Nakamura, 2022. "Periosteal stem cells control growth plate stem cells during postnatal skeletal growth," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    5. Diego A. Garzón-Alvarado, 2014. "A biochemical strategy for simulation of endochondral and intramembranous ossification," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 17(11), pages 1237-1247, August.
    6. Diego Garzón-Alvarado, 2011. "Can the size of the epiphysis determine the number of secondary ossification centers? A mathematical approach," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 14(09), pages 819-826.
    7. Żaneta Ciosek & Karolina Kot & Iwona Rotter, 2023. "Iron, Zinc, Copper, Cadmium, Mercury, and Bone Tissue," IJERPH, MDPI, vol. 20(3), pages 1-25, January.
    8. Johan Kerkhofs & Liesbet Geris, 2015. "A Semiquantitative Framework for Gene Regulatory Networks: Increasing the Time and Quantitative Resolution of Boolean Networks," PLOS ONE, Public Library of Science, vol. 10(6), pages 1-23, June.
    9. Chee Ho H’ng & Shanika L. Amarasinghe & Boya Zhang & Hojin Chang & Xinli Qu & David R. Powell & Alberto Rosello-Diez, 2024. "Compensatory growth and recovery of cartilage cytoarchitecture after transient cell death in fetal mouse limbs," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    10. Yuyao Tian & Wuming Wang & Sofie Lautrup & Hui Zhao & Xiang Li & Patrick Wai Nok Law & Ngoc-Duy Dinh & Evandro Fei Fang & Hoi Hung Cheung & Wai-Yee Chan, 2022. "WRN promotes bone development and growth by unwinding SHOX-G-quadruplexes via its helicase activity in Werner Syndrome," Nature Communications, Nature, vol. 13(1), pages 1-20, December.

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