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Neutralization of Omicron BA.1, BA.2, and BA.3 SARS-CoV-2 by 3 doses of BNT162b2 vaccine

Author

Listed:
  • Chaitanya Kurhade

    (University of Texas Medical Branch)

  • Jing Zou

    (University of Texas Medical Branch)

  • Hongjie Xia

    (University of Texas Medical Branch)

  • Hui Cai

    (Pfizer Vaccine Research and Development, Pearl River)

  • Qi Yang

    (Pfizer Vaccine Research and Development, Pearl River)

  • Mark Cutler

    (Pfizer Vaccine Research and Development, Pearl River)

  • David Cooper

    (Pfizer Vaccine Research and Development, Pearl River)

  • Alexander Muik

    (BioNTech)

  • Kathrin U. Jansen

    (Pfizer Vaccine Research and Development, Pearl River)

  • Xuping Xie

    (University of Texas Medical Branch)

  • Kena A. Swanson

    (Pfizer Vaccine Research and Development, Pearl River)

  • Pei‑Yong Shi

    (University of Texas Medical Branch)

Abstract

The newly emerged Omicron SARS-CoV-2 has several distinct sublineages including BA.1, BA.2, and BA.3. BA.1 accounts for the initial surge and is being replaced by BA.2, whereas BA.3 is at a low prevalence at this time. Here we report the neutralization of BNT162b2-vaccinated sera (collected 1 month after dose 3) against the three Omicron sublineages. To facilitate the neutralization testing, we have engineered the complete BA.1, BA.2, or BA.3 spike into an mNeonGreen USA-WA1/2020 SRAS-CoV-2. All BNT162b2-vaccinated sera neutralize USA-WA1/2020, BA.1-, BA.2-, and BA.3-spike SARS-CoV-2s with titers of >20; the neutralization geometric mean titers (GMTs) against the four viruses are 1211, 336, 300, and 190, respectively. Thus, the BA.1-, BA.2-, and BA.3-spike SARS-CoV-2s are 3.6-, 4.0-, and 6.4-fold less efficiently neutralized than the USA-WA1/2020, respectively. Our data have implications in vaccine strategy and understanding the biology of Omicron sublineages.

Suggested Citation

  • Chaitanya Kurhade & Jing Zou & Hongjie Xia & Hui Cai & Qi Yang & Mark Cutler & David Cooper & Alexander Muik & Kathrin U. Jansen & Xuping Xie & Kena A. Swanson & Pei‑Yong Shi, 2022. "Neutralization of Omicron BA.1, BA.2, and BA.3 SARS-CoV-2 by 3 doses of BNT162b2 vaccine," Nature Communications, Nature, vol. 13(1), pages 1-4, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-30681-1
    DOI: 10.1038/s41467-022-30681-1
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    1. Yubin Liu & Ziyi Wang & Xinyu Zhuang & Shengnan Zhang & Zhicheng Chen & Yan Zou & Jie Sheng & Tianpeng Li & Wanbo Tai & Jinfang Yu & Yanqun Wang & Zhaoyong Zhang & Yunfeng Chen & Liangqin Tong & Xi Yu, 2023. "Inactivated vaccine-elicited potent antibodies can broadly neutralize SARS-CoV-2 circulating variants," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

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