IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v13y2022i1d10.1038_s41467-022-28544-w.html
   My bibliography  Save this article

Neutralization against Omicron SARS-CoV-2 from previous non-Omicron infection

Author

Listed:
  • Jing Zou

    (University of Texas Medical Branch)

  • Hongjie Xia

    (University of Texas Medical Branch)

  • Xuping Xie

    (University of Texas Medical Branch)

  • Chaitanya Kurhade

    (University of Texas Medical Branch)

  • Rafael R. G. Machado

    (University of Texas Medical Branch)

  • Scott C. Weaver

    (University of Texas Medical Branch
    University of Texas Medical Branch)

  • Ping Ren

    (University of Texas Medical Branch)

  • Pei-Yong Shi

    (University of Texas Medical Branch
    University of Texas Medical Branch
    University of Texas Medical Branch
    University of Texas Medical Branch)

Abstract

The spread of the Omicron SARS-CoV-2 variant underscores the importance of analyzing the cross-protection from previous non-Omicron infection. We have developed a high-throughput neutralization assay for Omicron SARS-CoV-2 by engineering the Omicron spike gene into an mNeonGreen USA-WA1/2020 SARS-CoV-2 (isolated in January 2020). Using this assay, we determine the neutralization titers (defined as the maximal serum dilution that inhibited 50% of infectious virus) of patient sera collected at 1- or 6-months after infection with non-Omicron SARS-CoV-2. From 1- to 6-month post-infection, the neutralization titers against USA-WA1/2020 decrease from 601 to 142 (a 4.2-fold reduction), while the neutralization titers against Omicron-spike SARS-CoV-2 remain low at 38 and 32, respectively. Thus, at 1- and 6-months after non-Omicron SARS-CoV-2 infection, the neutralization titers against Omicron are 15.8- and 4.4-fold lower than those against USA-WA1/2020, respectively. The low cross-neutralization against Omicron from previous non-Omicron infection supports vaccination of formerly infected individuals to mitigate the health impact of the ongoing Omicron surge.

Suggested Citation

  • Jing Zou & Hongjie Xia & Xuping Xie & Chaitanya Kurhade & Rafael R. G. Machado & Scott C. Weaver & Ping Ren & Pei-Yong Shi, 2022. "Neutralization against Omicron SARS-CoV-2 from previous non-Omicron infection," Nature Communications, Nature, vol. 13(1), pages 1-4, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-28544-w
    DOI: 10.1038/s41467-022-28544-w
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-022-28544-w
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-022-28544-w?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Antonio E. Muruato & Camila R. Fontes-Garfias & Ping Ren & Mariano A. Garcia-Blanco & Vineet D. Menachery & Xuping Xie & Pei-Yong Shi, 2020. "A high-throughput neutralizing antibody assay for COVID-19 diagnosis and vaccine evaluation," Nature Communications, Nature, vol. 11(1), pages 1-6, December.
    2. Zhiqiang Ku & Xuping Xie & Edgar Davidson & Xiaohua Ye & Hang Su & Vineet D. Menachery & Yize Li & Zihao Yuan & Xianwen Zhang & Antonio E. Muruato & Ariadna Grinyo i Escuer & Breanna Tyrell & Kyle Doo, 2021. "Author Correction: Molecular determinants and mechanism for antibody cocktail preventing SARS-CoV-2 escape," Nature Communications, Nature, vol. 12(1), pages 1-1, December.
    3. Zhiqiang Ku & Xuping Xie & Edgar Davidson & Xiaohua Ye & Hang Su & Vineet D. Menachery & Yize Li & Zihao Yuan & Xianwen Zhang & Antonio E. Muruato & Ariadna Grinyo i Escuer & Breanna Tyrell & Kyle Doo, 2021. "Molecular determinants and mechanism for antibody cocktail preventing SARS-CoV-2 escape," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Chaitanya Kurhade & Jing Zou & Hongjie Xia & Hui Cai & Qi Yang & Mark Cutler & David Cooper & Alexander Muik & Kathrin U. Jansen & Xuping Xie & Kena A. Swanson & Pei‑Yong Shi, 2022. "Neutralization of Omicron BA.1, BA.2, and BA.3 SARS-CoV-2 by 3 doses of BNT162b2 vaccine," Nature Communications, Nature, vol. 13(1), pages 1-4, December.
    2. Jing Zou & Chaitanya Kurhade & Hongjie Xia & Mingru Liu & Xuping Xie & Ping Ren & Pei-Yong Shi, 2022. "Cross-neutralization of Omicron BA.1 against BA.2 and BA.3 SARS-CoV-2," Nature Communications, Nature, vol. 13(1), pages 1-5, December.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Yang Liu & Xianwen Zhang & Jianying Liu & Hongjie Xia & Jing Zou & Antonio E. Muruato & Sivakumar Periasamy & Chaitanya Kurhade & Jessica A. Plante & Nathen E. Bopp & Birte Kalveram & Alexander Bukrey, 2022. "A live-attenuated SARS-CoV-2 vaccine candidate with accessory protein deletions," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    2. Zhiqiang Ku & Xuping Xie & Jianqing Lin & Peng Gao & Bin Wu & Abbas El Sahili & Hang Su & Yang Liu & Xiaohua Ye & Eddie Yongjun Tan & Xin Li & Xuejun Fan & Boon Chong Goh & Wei Xiong & Hannah Boyd & A, 2022. "Engineering SARS-CoV-2 specific cocktail antibodies into a bispecific format improves neutralizing potency and breadth," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    3. Sissy Therese Sonnleitner & Martina Prelog & Stefanie Sonnleitner & Eva Hinterbichler & Hannah Halbfurter & Dominik B. C. Kopecky & Giovanni Almanzar & Stephan Koblmüller & Christian Sturmbauer & Leon, 2022. "Cumulative SARS-CoV-2 mutations and corresponding changes in immunity in an immunocompromised patient indicate viral evolution within the host," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    4. Biao Zhou & Runhong Zhou & Bingjie Tang & Jasper Fuk-Woo Chan & Mengxiao Luo & Qiaoli Peng & Shuofeng Yuan & Hang Liu & Bobo Wing-Yee Mok & Bohao Chen & Pui Wang & Vincent Kwok-Man Poon & Hin Chu & Ch, 2022. "A broadly neutralizing antibody protects Syrian hamsters against SARS-CoV-2 Omicron challenge," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    5. Romain Rouet & Jake Y. Henry & Matt D. Johansen & Meghna Sobti & Harikrishnan Balachandran & David B. Langley & Gregory J. Walker & Helen Lenthall & Jennifer Jackson & Stephanie Ubiparipovic & Ohan Ma, 2023. "Broadly neutralizing SARS-CoV-2 antibodies through epitope-based selection from convalescent patients," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    6. Amanda R. Goldberg & Kate E. Langwig & Katherine L. Brown & Jeffrey M. Marano & Pallavi Rai & Kelsie M. King & Amanda K. Sharp & Alessandro Ceci & Christopher D. Kailing & Macy J. Kailing & Russell Br, 2024. "Widespread exposure to SARS-CoV-2 in wildlife communities," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    7. Sun Jin Kim & Zhong Yao & Morgan C. Marsh & Debra M. Eckert & Michael S. Kay & Anna Lyakisheva & Maria Pasic & Aiyush Bansal & Chaim Birnboim & Prabhat Jha & Yannick Galipeau & Marc-André Langlois & J, 2022. "Homogeneous surrogate virus neutralization assay to rapidly assess neutralization activity of anti-SARS-CoV-2 antibodies," Nature Communications, Nature, vol. 13(1), pages 1-9, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-28544-w. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.