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Cross-neutralization of Omicron BA.1 against BA.2 and BA.3 SARS-CoV-2

Author

Listed:
  • Jing Zou

    (University of Texas Medical Branch)

  • Chaitanya Kurhade

    (University of Texas Medical Branch)

  • Hongjie Xia

    (University of Texas Medical Branch)

  • Mingru Liu

    (University of Texas Medical Branch)

  • Xuping Xie

    (University of Texas Medical Branch)

  • Ping Ren

    (University of Texas Medical Branch)

  • Pei-Yong Shi

    (University of Texas Medical Branch
    University of Texas Medical Branch
    University of Texas Medical Branch
    University of Texas Medical Branch)

Abstract

The Omicron SARS-CoV-2 has several distinct sublineages, among which sublineage BA.1 is responsible for the initial Omicron surge and is now being replaced by BA.2 worldwide, whereas BA.3 is currently at a low frequency. The ongoing BA.1-to-BA.2 replacement underscores the importance to understand the cross-neutralization among the three Omicron sublineages. Here we test the neutralization of BA.1-infected human sera against BA.2, BA.3, and USA/WA1-2020 (a strain isolated in late January 2020). The BA.1-infected sera neutralize BA.1, BA.2, BA.3, and USA/WA1-2020 SARS-CoV-2s with geometric mean titers (GMTs) of 445, 107, 102, and 16, respectively. Thus, the neutralizing GMTs against heterologous BA.2, BA.3, and USA/WA1-2020 are 4.2-, 4.4-, and 28.4-fold lower than the GMT against homologous BA.1, respectively. These findings have implications in COVID-19 vaccine strategy.

Suggested Citation

  • Jing Zou & Chaitanya Kurhade & Hongjie Xia & Mingru Liu & Xuping Xie & Ping Ren & Pei-Yong Shi, 2022. "Cross-neutralization of Omicron BA.1 against BA.2 and BA.3 SARS-CoV-2," Nature Communications, Nature, vol. 13(1), pages 1-5, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-30580-5
    DOI: 10.1038/s41467-022-30580-5
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    1. Jing Zou & Hongjie Xia & Xuping Xie & Chaitanya Kurhade & Rafael R. G. Machado & Scott C. Weaver & Ping Ren & Pei-Yong Shi, 2022. "Neutralization against Omicron SARS-CoV-2 from previous non-Omicron infection," Nature Communications, Nature, vol. 13(1), pages 1-4, December.
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