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Subthalamic nucleus stabilizes movements by reducing neural spike variability in monkey basal ganglia

Author

Listed:
  • Taku Hasegawa

    (National Institute for Physiological Sciences)

  • Satomi Chiken

    (National Institute for Physiological Sciences
    SOKENDAI)

  • Kenta Kobayashi

    (SOKENDAI
    Section of Viral Vector Development, National Institute for Physiological Sciences)

  • Atsushi Nambu

    (National Institute for Physiological Sciences
    SOKENDAI
    Section of Viral Vector Development, National Institute for Physiological Sciences)

Abstract

The subthalamic nucleus projects to the external and internal pallidum, the modulatory and output nuclei of the basal ganglia, respectively, and plays an indispensable role in controlling voluntary movements. However, the precise mechanism by which the subthalamic nucleus controls pallidal activity and movements remains elusive. Here, we utilize chemogenetics to reversibly reduce neural activity of the motor subregion of the subthalamic nucleus in three macaque monkeys (Macaca fuscata, both sexes) during a reaching task. Systemic administration of chemogenetic ligands prolongs movement time and increases spike train variability in the pallidum, but only slightly affects firing rate modulations. Across-trial analyses reveal that the irregular discharges in the pallidum coincides with prolonged movement time. Reduction of subthalamic activity also induces excessive abnormal movements in the contralateral forelimb, which are preceded by subthalamic and pallidal phasic activity changes. Our results suggest that the subthalamic nucleus stabilizes pallidal spike trains and achieves stable movements.

Suggested Citation

  • Taku Hasegawa & Satomi Chiken & Kenta Kobayashi & Atsushi Nambu, 2022. "Subthalamic nucleus stabilizes movements by reducing neural spike variability in monkey basal ganglia," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-29750-2
    DOI: 10.1038/s41467-022-29750-2
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    References listed on IDEAS

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    1. Dietmar Plenz & Stephen T. Kital, 1999. "A basal ganglia pacemaker formed by the subthalamic nucleus and external globus pallidus," Nature, Nature, vol. 400(6745), pages 677-682, August.
    2. Jeremiah Y. Cohen & Sebastian Haesler & Linh Vong & Bradford B. Lowell & Naoshige Uchida, 2012. "Neuron-type-specific signals for reward and punishment in the ventral tegmental area," Nature, Nature, vol. 482(7383), pages 85-88, February.
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    1. Catherine Elorette & Atsushi Fujimoto & Frederic M. Stoll & Satoka H. Fujimoto & Niranjana Bienkowska & Liza London & Lazar Fleysher & Brian E. Russ & Peter H. Rudebeck, 2024. "The neural basis of resting-state fMRI functional connectivity in fronto-limbic circuits revealed by chemogenetic manipulation," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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