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Stress-driven potentiation of lateral hypothalamic synapses onto ventral tegmental area dopamine neurons causes increased consumption of palatable food

Author

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  • Louisa E. Linders

    (Utrecht University)

  • Lefkothea Patrikiou

    (Utrecht University)

  • Mariano Soiza-Reilly

    (University of Buenos Aires)

  • Evelien H. S. Schut

    (Utrecht University)

  • Bram F. Schaffelaar

    (Utrecht University)

  • Leonard Böger

    (Utrecht University)

  • Inge G. Wolterink-Donselaar

    (Utrecht University)

  • Mieneke C. M. Luijendijk

    (Utrecht University)

  • Roger A. H. Adan

    (Utrecht University)

  • Frank J. Meye

    (Utrecht University)

Abstract

Stress can cause overconsumption of palatable high caloric food. Despite the important role of stress eating in obesity and (binge) eating disorders, its underlying neural mechanisms remain unclear. Here we demonstrate in mice that stress alters lateral hypothalamic area (LHA) control over the ventral tegmental area (VTA), thereby promoting overconsumption of palatable food. Specifically, we show that glutamatergic LHA neurons projecting to the VTA are activated by social stress, after which their synapses onto dopamine neurons are potentiated via AMPA receptor subunit alterations. We find that stress-driven strengthening of these specific synapses increases LHA control over dopamine output in key target areas like the prefrontal cortex. Finally, we demonstrate that while inducing LHA-VTA glutamatergic potentiation increases palatable fat intake, reducing stress-driven potentiation of this connection prevents such stress eating. Overall, this study provides insights in the neural circuit adaptations caused by stress that drive overconsumption of palatable food.

Suggested Citation

  • Louisa E. Linders & Lefkothea Patrikiou & Mariano Soiza-Reilly & Evelien H. S. Schut & Bram F. Schaffelaar & Leonard Böger & Inge G. Wolterink-Donselaar & Mieneke C. M. Luijendijk & Roger A. H. Adan &, 2022. "Stress-driven potentiation of lateral hypothalamic synapses onto ventral tegmental area dopamine neurons causes increased consumption of palatable food," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
  • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-34625-7
    DOI: 10.1038/s41467-022-34625-7
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    References listed on IDEAS

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    1. Jeremiah Y. Cohen & Sebastian Haesler & Linh Vong & Bradford B. Lowell & Naoshige Uchida, 2012. "Neuron-type-specific signals for reward and punishment in the ventral tegmental area," Nature, Nature, vol. 482(7383), pages 85-88, February.
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    Cited by:

    1. In-Jee You & Yeeun Bae & Alec R. Beck & Sora Shin, 2023. "Lateral hypothalamic proenkephalin neurons drive threat-induced overeating associated with a negative emotional state," Nature Communications, Nature, vol. 14(1), pages 1-20, December.

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