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Neuron-type-specific signals for reward and punishment in the ventral tegmental area

Author

Listed:
  • Jeremiah Y. Cohen

    (Center for Brain Science, Harvard University)

  • Sebastian Haesler

    (Center for Brain Science, Harvard University)

  • Linh Vong

    (Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Bradford B. Lowell

    (Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Naoshige Uchida

    (Center for Brain Science, Harvard University)

Abstract

Dopaminergic neurons in the mouse ventral tegmental area signal the difference between received and expected reward, whereas GABAergic neurons signal expected reward.

Suggested Citation

  • Jeremiah Y. Cohen & Sebastian Haesler & Linh Vong & Bradford B. Lowell & Naoshige Uchida, 2012. "Neuron-type-specific signals for reward and punishment in the ventral tegmental area," Nature, Nature, vol. 482(7383), pages 85-88, February.
    • Handle: RePEc:nat:nature:v:482:y:2012:i:7383:d:10.1038_nature10754
    DOI: 10.1038/nature10754
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    Cited by:

    1. Athina Tzovara & Christoph W Korn & Dominik R Bach, 2018. "Human Pavlovian fear conditioning conforms to probabilistic learning," PLOS Computational Biology, Public Library of Science, vol. 14(8), pages 1-21, August.
    2. Terence C. Burnham & Jay Phelan, 2021. "Ordinaries," Journal of Bioeconomics, Springer, vol. 23(2), pages 125-149, July.
    3. Taku Hasegawa & Satomi Chiken & Kenta Kobayashi & Atsushi Nambu, 2022. "Subthalamic nucleus stabilizes movements by reducing neural spike variability in monkey basal ganglia," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    4. Torben Ott & Anna Marlina Stein & Andreas Nieder, 2023. "Dopamine receptor activation regulates reward expectancy signals during cognitive control in primate prefrontal neurons," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    5. Terence C. Burnham & Jay Phelan, 2020. "Ordinaries," Journal of Bioeconomics, Springer, vol. 22(2), pages 63-76, July.
    6. Allen P. F. Chen & Jeffrey M. Malgady & Lu Chen & Kaiyo W. Shi & Eileen Cheng & Joshua L. Plotkin & Shaoyu Ge & Qiaojie Xiong, 2022. "Nigrostriatal dopamine pathway regulates auditory discrimination behavior," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    7. Louisa E. Linders & Lefkothea Patrikiou & Mariano Soiza-Reilly & Evelien H. S. Schut & Bram F. Schaffelaar & Leonard Böger & Inge G. Wolterink-Donselaar & Mieneke C. M. Luijendijk & Roger A. H. Adan &, 2022. "Stress-driven potentiation of lateral hypothalamic synapses onto ventral tegmental area dopamine neurons causes increased consumption of palatable food," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    8. Panna Hegedüs & Bálint Király & Dániel Schlingloff & Victoria Lyakhova & Anna Velencei & Írisz Szabó & Márton I. Mayer & Zsofia Zelenak & Gábor Nyiri & Balázs Hangya, 2024. "Parvalbumin-expressing basal forebrain neurons mediate learning from negative experience," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    9. Huanyuan Zhou & KongFatt Wong-Lin & Da-Hui Wang, 2018. "Parallel Excitatory and Inhibitory Neural Circuit Pathways Underlie Reward-Based Phasic Neural Responses," Complexity, Hindawi, vol. 2018, pages 1-20, April.
    10. Hong Yu & Xinkuan Xiang & Zongming Chen & Xu Wang & Jiaqi Dai & Xinxin Wang & Pengcheng Huang & Zheng-dong Zhao & Wei L. Shen & Haohong Li, 2021. "Periaqueductal gray neurons encode the sequential motor program in hunting behavior of mice," Nature Communications, Nature, vol. 12(1), pages 1-15, December.
    11. Lizhu Li & Lihui Lu & Yuqi Ren & Guo Tang & Yu Zhao & Xue Cai & Zhao Shi & He Ding & Changbo Liu & Dali Cheng & Yang Xie & Huachun Wang & Xin Fu & Lan Yin & Minmin Luo & Xing Sheng, 2022. "Colocalized, bidirectional optogenetic modulations in freely behaving mice with a wireless dual-color optoelectronic probe," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    12. Li Shen & Guang-Wei Zhang & Can Tao & Michelle B. Seo & Nicole K. Zhang & Junxiang J. Huang & Li I. Zhang & Huizhong W. Tao, 2022. "A bottom-up reward pathway mediated by somatostatin neurons in the medial septum complex underlying appetitive learning," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    13. Bernard Bloem & Rafiq Huda & Ken-ichi Amemori & Alex S. Abate & Gayathri Krishna & Anna L. Wilson & Cody W. Carter & Mriganka Sur & Ann M. Graybiel, 2022. "Multiplexed action-outcome representation by striatal striosome-matrix compartments detected with a mouse cost-benefit foraging task," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    14. Laurens Winkelmeier & Carla Filosa & Renée Hartig & Max Scheller & Markus Sack & Jonathan R. Reinwald & Robert Becker & David Wolf & Martin Fungisai Gerchen & Alexander Sartorius & Andreas Meyer-Linde, 2022. "Striatal hub of dynamic and stabilized prediction coding in forebrain networks for olfactory reinforcement learning," Nature Communications, Nature, vol. 13(1), pages 1-21, December.
    15. Rosalba Morese & Daniela Rabellino & Fabio Sambataro & Felice Perussia & Maria Consuelo Valentini & Bruno G Bara & Francesca M Bosco, 2016. "Group Membership Modulates the Neural Circuitry Underlying Third Party Punishment," PLOS ONE, Public Library of Science, vol. 11(11), pages 1-14, November.

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