IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v400y1999i6745d10.1038_23281.html
   My bibliography  Save this article

A basal ganglia pacemaker formed by the subthalamic nucleus and external globus pallidus

Author

Listed:
  • Dietmar Plenz

    (University of Tennessee, College of Medicine
    National Institute of Mental Health)

  • Stephen T. Kital

    (University of Tennessee, College of Medicine)

Abstract

The subthalamic nucleus of the basal ganglia (STN) is important for normal movement1,2 as well as in movement disorders3,4,5. Lesioning6 or deep-brain stimulation7,8 of the STN can alleviate resting tremor in Parkinson's disease. The STN5 and its target nuclei9,10 display synchronized oscillatory burst discharge at low frequencies, some of which correlate with tremor, but the mechanism underlying this synchronized bursting is unknown. Here we show that the excitatory STN and inhibitory, external globus pallidus (GPe) form a feedback system that engages in synchronized bursting. In mature organotypic cortex–striatum–STN–GPe cultures, neurons in the STN and GPe spontaneously produce synchronized oscillating bursts at 0.4, 0.8 and 1.8 Hz. Pallidal lesion abolishes this bursting, whereas cortical lesion favours bursting at 0.8 Hz. Pallidal bursts, although weaker than STN bursts, were required for synchronized oscillatory burst generation by recruitment of subthalmic rebound excitation. We propose that the STN and GPe constitute a central pacemaker modulated by striatal inhibition of GPe neurons. This pacemaker could be responsible for synchronized oscillatory activity in the normal and pathological basal ganglia.

Suggested Citation

  • Dietmar Plenz & Stephen T. Kital, 1999. "A basal ganglia pacemaker formed by the subthalamic nucleus and external globus pallidus," Nature, Nature, vol. 400(6745), pages 677-682, August.
    • Handle: RePEc:nat:nature:v:400:y:1999:i:6745:d:10.1038_23281
    DOI: 10.1038/23281
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/23281
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/23281?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Sanzeni, A. & Celani, A. & Tiana, G. & Vergassola, M., 2016. "Theory of feedback controlled brain stimulations for Parkinson’s disease," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 441(C), pages 121-130.
    2. Yu, Ying & Zhang, Honghui & Zhang, Liyuan & Wang, Qingyun, 2019. "Dynamical role of pedunculopntine nucleus stimulation on controlling Parkinson’s disease," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 525(C), pages 834-848.
    3. Taku Hasegawa & Satomi Chiken & Kenta Kobayashi & Atsushi Nambu, 2022. "Subthalamic nucleus stabilizes movements by reducing neural spike variability in monkey basal ganglia," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    4. Rosalyn J Moran & Nicolas Mallet & Vladimir Litvak & Raymond J Dolan & Peter J Magill & Karl J Friston & Peter Brown, 2011. "Alterations in Brain Connectivity Underlying Beta Oscillations in Parkinsonism," PLOS Computational Biology, Public Library of Science, vol. 7(8), pages 1-15, August.
    5. Lior Tiroshi & Joshua A Goldberg, 2019. "Population dynamics and entrainment of basal ganglia pacemakers are shaped by their dendritic arbors," PLOS Computational Biology, Public Library of Science, vol. 15(2), pages 1-29, February.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:400:y:1999:i:6745:d:10.1038_23281. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.