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Randomized controlled trial for time-restricted eating in healthy volunteers without obesity

Author

Listed:
  • Zhibo Xie

    (PUMC & Chinese Academy of Medical Sciences)

  • Yuning Sun

    (PUMC & Chinese Academy of Medical Sciences)

  • Yuqian Ye

    (PUMC & Chinese Academy of Medical Sciences
    Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Dandan Hu

    (PUMC & Chinese Academy of Medical Sciences
    Sun Yat-sen University Cancer Center)

  • Hua Zhang

    (PUMC & Chinese Academy of Medical Sciences)

  • Zhangyuting He

    (PUMC & Chinese Academy of Medical Sciences)

  • Haitao Zhao

    (PUMC & Chinese Academy of Medical Sciences)

  • Huayu Yang

    (PUMC & Chinese Academy of Medical Sciences)

  • Yilei Mao

    (PUMC & Chinese Academy of Medical Sciences)

Abstract

Time-restricted feeding (TRF) improves metabolic health. Both early TRF (eTRF, food intake restricted to the early part of the day) and mid-day TRF (mTRF, food intake restricted to the middle of the day) have been shown to have metabolic benefits. However, the two regimens have yet to be thoroughly compared. We conducted a five-week randomized trial to compare the effects of the two TRF regimens in healthy individuals without obesity (ChiCTR2000029797). The trial has completed. Ninety participants were randomized to eTRF (n=30), mTRF (n=30), or control groups (n=30) using a computer-based random-number generator. Eighty-two participants completed the entire five-week trial and were analyzed (28 in eTRF, 26 in mTRF, 28 in control groups). The primary outcome was the change in insulin resistance. Researchers who assessed the outcomes were blinded to group assignment, but participants and care givers were not. Here we show that eTRF was more effective than mTRF at improving insulin sensitivity. Furthermore, eTRF, but not mTRF, improved fasting glucose, reduced total body mass and adiposity, ameliorated inflammation, and increased gut microbial diversity. No serious adverse events were reported during the trial. In conclusion, eTRF showed greater benefits for insulin resistance and related metabolic parameters compared with mTRF. Clinical Trial Registration URL: http://www.chictr.org.cn/showproj.aspx?proj=49406 .

Suggested Citation

  • Zhibo Xie & Yuning Sun & Yuqian Ye & Dandan Hu & Hua Zhang & Zhangyuting He & Haitao Zhao & Huayu Yang & Yilei Mao, 2022. "Randomized controlled trial for time-restricted eating in healthy volunteers without obesity," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
  • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-28662-5
    DOI: 10.1038/s41467-022-28662-5
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    References listed on IDEAS

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    1. Emmanuelle Le Chatelier & Trine Nielsen & Junjie Qin & Edi Prifti & Falk Hildebrand & Gwen Falony & Mathieu Almeida & Manimozhiyan Arumugam & Jean-Michel Batto & Sean Kennedy & Pierre Leonard & Junhua, 2013. "Richness of human gut microbiome correlates with metabolic markers," Nature, Nature, vol. 500(7464), pages 541-546, August.
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    1. Anna Palomar-Cros & Valentina A. Andreeva & Léopold K. Fezeu & Chantal Julia & Alice Bellicha & Emmanuelle Kesse-Guyot & Serge Hercberg & Dora Romaguera & Manolis Kogevinas & Mathilde Touvier & Bernar, 2023. "Dietary circadian rhythms and cardiovascular disease risk in the prospective NutriNet-Santé cohort," Nature Communications, Nature, vol. 14(1), pages 1-12, December.

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