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Atomically unveiling the structure-activity relationship of biomacromolecule-metal-organic frameworks symbiotic crystal

Author

Listed:
  • Linjing Tong

    (Sun Yat-sen University)

  • Siming Huang

    (Guangzhou Medical University)

  • Yujian Shen

    (Sun Yat-sen University)

  • Suya Liu

    (Shanghai Nanoport, Thermo Fisher Scientific)

  • Xiaomin Ma

    (Southern University of Science and Technology)

  • Fang Zhu

    (Sun Yat-sen University)

  • Guosheng Chen

    (Sun Yat-sen University)

  • Gangfeng Ouyang

    (Sun Yat-sen University)

Abstract

Crystallization of biomacromolecules-metal-organic frameworks (BMOFs) allows for orderly assemble of symbiotic hybrids with desirable biological and chemical functions in one voxel. The structure-activity relationship of this symbiotic crystal, however, is still blurred. Here, we directly identify the atomic-level structure of BMOFs, using the integrated differential phase contrast-scanning transmission electron microscopy, cryo-electron microscopy and x-ray absorption fine structure techniques. We discover an obvious difference in the nanoarchitecture of BMOFs under different crystallization pathways that was previously not seen. In addition, we find the nanoarchitecture significantly affects the bioactivity of the BMOFs. This work gives an important insight into the structure-activity relationship of BMOFs synthesized in different scenarios, and may act as a guide to engineer next-generation materials with excellent biological and chemical functions.

Suggested Citation

  • Linjing Tong & Siming Huang & Yujian Shen & Suya Liu & Xiaomin Ma & Fang Zhu & Guosheng Chen & Gangfeng Ouyang, 2022. "Atomically unveiling the structure-activity relationship of biomacromolecule-metal-organic frameworks symbiotic crystal," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-28615-y
    DOI: 10.1038/s41467-022-28615-y
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    Cited by:

    1. Guosheng Chen & Linjing Tong & Siming Huang & Shuyao Huang & Fang Zhu & Gangfeng Ouyang, 2022. "Hydrogen-bonded organic framework biomimetic entrapment allowing non-native biocatalytic activity in enzyme," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    2. Wei Huang & Haitao Yuan & Huangsheng Yang & Xiaomin Ma & Shuyao Huang & Hongjie Zhang & Siming Huang & Guosheng Chen & Gangfeng Ouyang, 2023. "Green synthesis of stable hybrid biocatalyst using a hydrogen-bonded, π-π-stacking supramolecular assembly for electrochemical immunosensor," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    3. Pooja Sindhu & K. S. Ananthram & Anil Jain & Kartick Tarafder & Nirmalya Ballav, 2023. "Insulator-to-metal-like transition in thin films of a biological metal-organic framework," Nature Communications, Nature, vol. 14(1), pages 1-9, December.

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