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Bioinspired porous three-coordinated single-atom Fe nanozyme with oxidase-like activity for tumor visual identification via glutathione

Author

Listed:
  • Da Chen

    (Northwestern Polytechnical University)

  • Zhaoming Xia

    (Southern University of Science and Technology)

  • Zhixiong Guo

    (Northwestern Polytechnical University)

  • Wangyan Gou

    (Northwestern Polytechnical University)

  • Junlong Zhao

    (Fourth Military Medical University)

  • Xuemei Zhou

    (Wenzhou University)

  • Xiaohe Tan

    (Northwestern Polytechnical University)

  • Wenbin Li

    (Northwestern Polytechnical University)

  • Shoujie Zhao

    (Fourth Military Medical University)

  • Zhimin Tian

    (Northwestern Polytechnical University)

  • Yongquan Qu

    (Northwestern Polytechnical University)

Abstract

Inspired by structures of natural metalloenzymes, a biomimetic synthetic strategy is developed for scalable synthesis of porous Fe-N3 single atom nanozymes (pFeSAN) using hemoglobin as Fe-source and template. pFeSAN delivers 3.3- and 8791-fold higher oxidase-like activity than Fe-N4 and Fe3O4 nanozymes. The high catalytic performance is attributed to (1) the suppressed aggregation of atomically dispersed Fe; (2) facilitated mass transfer and maximized exposure of active sites for the created mesopores by thermal removal of hemoglobin (2 ~ 3 nm); and (3) unique electronic configuration of Fe-N3 for the oxygen-to-water oxidation pathway (analogy with natural cytochrome c oxidase). The pFeSAN is successfully demonstrated for the rapid colorimetric detection of glutathione with a low limit of detection (2.4 nM) and wide range (50 nM–1 mM), and further developed as a real-time, facile, rapid (~6 min) and precise visualization analysis methodology of tumors via glutathione level, showing its potentials for diagnostic and clinic applications.

Suggested Citation

  • Da Chen & Zhaoming Xia & Zhixiong Guo & Wangyan Gou & Junlong Zhao & Xuemei Zhou & Xiaohe Tan & Wenbin Li & Shoujie Zhao & Zhimin Tian & Yongquan Qu, 2023. "Bioinspired porous three-coordinated single-atom Fe nanozyme with oxidase-like activity for tumor visual identification via glutathione," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-42889-w
    DOI: 10.1038/s41467-023-42889-w
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    References listed on IDEAS

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    1. Kang Liang & Raffaele Ricco & Cara M. Doherty & Mark J. Styles & Stephen Bell & Nigel Kirby & Stephen Mudie & David Haylock & Anita J. Hill & Christian J. Doonan & Paolo Falcaro, 2015. "Biomimetic mineralization of metal-organic frameworks as protective coatings for biomacromolecules," Nature Communications, Nature, vol. 6(1), pages 1-8, November.
    2. Liping Huang & Hongwei Sun & Liangbin Sun & Keqing Shi & Yuzhe Chen & Xueqian Ren & Yuancai Ge & Danfeng Jiang & Xiaohu Liu & Wolfgang Knoll & Qingwen Zhang & Yi Wang, 2023. "Rapid, label-free histopathological diagnosis of liver cancer based on Raman spectroscopy and deep learning," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
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