IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v14y2023i1d10.1038_s41467-023-42889-w.html
   My bibliography  Save this article

Bioinspired porous three-coordinated single-atom Fe nanozyme with oxidase-like activity for tumor visual identification via glutathione

Author

Listed:
  • Da Chen

    (Northwestern Polytechnical University)

  • Zhaoming Xia

    (Southern University of Science and Technology)

  • Zhixiong Guo

    (Northwestern Polytechnical University)

  • Wangyan Gou

    (Northwestern Polytechnical University)

  • Junlong Zhao

    (Fourth Military Medical University)

  • Xuemei Zhou

    (Wenzhou University)

  • Xiaohe Tan

    (Northwestern Polytechnical University)

  • Wenbin Li

    (Northwestern Polytechnical University)

  • Shoujie Zhao

    (Fourth Military Medical University)

  • Zhimin Tian

    (Northwestern Polytechnical University)

  • Yongquan Qu

    (Northwestern Polytechnical University)

Abstract

Inspired by structures of natural metalloenzymes, a biomimetic synthetic strategy is developed for scalable synthesis of porous Fe-N3 single atom nanozymes (pFeSAN) using hemoglobin as Fe-source and template. pFeSAN delivers 3.3- and 8791-fold higher oxidase-like activity than Fe-N4 and Fe3O4 nanozymes. The high catalytic performance is attributed to (1) the suppressed aggregation of atomically dispersed Fe; (2) facilitated mass transfer and maximized exposure of active sites for the created mesopores by thermal removal of hemoglobin (2 ~ 3 nm); and (3) unique electronic configuration of Fe-N3 for the oxygen-to-water oxidation pathway (analogy with natural cytochrome c oxidase). The pFeSAN is successfully demonstrated for the rapid colorimetric detection of glutathione with a low limit of detection (2.4 nM) and wide range (50 nM–1 mM), and further developed as a real-time, facile, rapid (~6 min) and precise visualization analysis methodology of tumors via glutathione level, showing its potentials for diagnostic and clinic applications.

Suggested Citation

  • Da Chen & Zhaoming Xia & Zhixiong Guo & Wangyan Gou & Junlong Zhao & Xuemei Zhou & Xiaohe Tan & Wenbin Li & Shoujie Zhao & Zhimin Tian & Yongquan Qu, 2023. "Bioinspired porous three-coordinated single-atom Fe nanozyme with oxidase-like activity for tumor visual identification via glutathione," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-42889-w
    DOI: 10.1038/s41467-023-42889-w
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-023-42889-w
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-023-42889-w?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Liping Huang & Hongwei Sun & Liangbin Sun & Keqing Shi & Yuzhe Chen & Xueqian Ren & Yuancai Ge & Danfeng Jiang & Xiaohu Liu & Wolfgang Knoll & Qingwen Zhang & Yi Wang, 2023. "Rapid, label-free histopathological diagnosis of liver cancer based on Raman spectroscopy and deep learning," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    2. Kang Liang & Raffaele Ricco & Cara M. Doherty & Mark J. Styles & Stephen Bell & Nigel Kirby & Stephen Mudie & David Haylock & Anita J. Hill & Christian J. Doonan & Paolo Falcaro, 2015. "Biomimetic mineralization of metal-organic frameworks as protective coatings for biomacromolecules," Nature Communications, Nature, vol. 6(1), pages 1-8, November.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Linjing Tong & Siming Huang & Yujian Shen & Suya Liu & Xiaomin Ma & Fang Zhu & Guosheng Chen & Gangfeng Ouyang, 2022. "Atomically unveiling the structure-activity relationship of biomacromolecule-metal-organic frameworks symbiotic crystal," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
    2. Wei Huang & Haitao Yuan & Huangsheng Yang & Xiaomin Ma & Shuyao Huang & Hongjie Zhang & Siming Huang & Guosheng Chen & Gangfeng Ouyang, 2023. "Green synthesis of stable hybrid biocatalyst using a hydrogen-bonded, π-π-stacking supramolecular assembly for electrochemical immunosensor," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    3. Guosheng Chen & Linjing Tong & Siming Huang & Shuyao Huang & Fang Zhu & Gangfeng Ouyang, 2022. "Hydrogen-bonded organic framework biomimetic entrapment allowing non-native biocatalytic activity in enzyme," Nature Communications, Nature, vol. 13(1), pages 1-10, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-42889-w. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.