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Pediatric COVID-19 patients in South Brazil show abundant viral mRNA and strong specific anti-viral responses

Author

Listed:
  • Tiago Fazolo

    (Universidade Federal de Ciências da Saúde de Porto Alegre - UFCSPA)

  • Karina Lima

    (Universidade Federal de Ciências da Saúde de Porto Alegre - UFCSPA)

  • Julia C. Fontoura

    (Universidade Federal de Ciências da Saúde de Porto Alegre - UFCSPA)

  • Priscila Oliveira Souza

    (Universidade Federal de Ciências da Saúde de Porto Alegre - UFCSPA)

  • Gabriel Hilario

    (Universidade Federal de Ciências da Saúde de Porto Alegre - UFCSPA)

  • Renata Zorzetto

    (Universidade Federal de Ciências da Saúde de Porto Alegre - UFCSPA)

  • Luiz Rodrigues Júnior

    (Universidade Federal de Ciências da Saúde de Porto Alegre - UFCSPA)

  • Veridiane Maria Pscheidt

    (Universidade Federal de Ciências da Saúde de Porto Alegre - UFCSPA)

  • Jayme Castilhos Ferreira Neto

    (Universidade Federal de Ciências da Saúde de Porto Alegre - UFCSPA)

  • Alisson F. Haubert

    (Universidade Federal de Ciências da Saúde de Porto Alegre - UFCSPA)

  • Izza Gambin

    (Universidade Federal de Ciências da Saúde de Porto Alegre - UFCSPA)

  • Aline C. Oliveira

    (Universidade Federal de Ciências da Saúde de Porto Alegre - UFCSPA)

  • Raissa S. Mello

    (Universidade Federal de Ciências da Saúde de Porto Alegre - UFCSPA)

  • Matheus Bastos Balbe e Gutierres

    (Universidade Federal de Ciências da Saúde de Porto Alegre - UFCSPA)

  • Rodrigo Benedetti Gassen

    (Massachusetts General Hospital, Harvard Medical School)

  • Lais Durço Coimbra

    (Brazilian Center for Research in Energy and Materials (CNPEM))

  • Alexandre Borin

    (Brazilian Center for Research in Energy and Materials (CNPEM))

  • Rafael Elias Marques

    (Brazilian Center for Research in Energy and Materials (CNPEM))

  • Ivaine Tais Sauthier Sartor

    (Hospital Moinhos de Vento)

  • Gabriela Oliveira Zavaglia

    (Hospital Moinhos de Vento)

  • Ingrid Rodrigues Fernandes

    (Hospital Moinhos de Vento)

  • Helder I. Nakaya

    (Hospital Israelita Albert Einstein)

  • Fernanda Hammes Varela

    (Hospital Moinhos de Vento
    Pontifícia Universidade Católica do Rio Grande do Sul - PUCRS)

  • Márcia Polese-Bonatto

    (Hospital Moinhos de Vento)

  • Thiago J. Borges

    (Massachusetts General Hospital, Harvard Medical School)

  • Sidia Maria Callegari-Jacques

    (Universidade Federal do Rio Grande do Sul)

  • Marcela Santos Correa Costa

    (Secretaria de vigilância em saúde - Ministério da Saúde (CGPNI/DEIDT/SVS/MS))

  • Jaqueline Araujo Schwartz

    (Secretaria de vigilância em saúde - Ministério da Saúde (CGPNI/DEIDT/SVS/MS))

  • Marcelo Comerlato Scotta

    (Hospital Moinhos de Vento
    Pontifícia Universidade Católica do Rio Grande do Sul - PUCRS)

  • Renato T. Stein

    (Hospital Moinhos de Vento
    Pontifícia Universidade Católica do Rio Grande do Sul - PUCRS)

  • Cristina Bonorino

    (Universidade Federal de Ciências da Saúde de Porto Alegre - UFCSPA
    University of California at San Diego - UCSD)

Abstract

COVID-19 manifests as a milder disease in children than adults, but the underlying mechanisms are not fully characterized. Here we assess the difference in cellular or humoral immune responses of pediatric and adult COVID-19 patients to see if these factors contribute to the severity dichotomy. Children’s non-specific immune profile is dominated by naive lymphocytes and HLA-DRhighCX3CR1low dendritic cells; meanwhile, children show strong specific antibody and T cell responses for viral structural proteins, with their T cell responses differing from adults by having weaker CD8+TNF+ T cells responses to S peptide pool but stronger responses to N and M peptide pools. Finally, viral mRNA is more abundant in pediatric patients. Our data thus support a scenario in which SARS-CoV-2 infected children contribute to transmission yet are less susceptible to COVID-19 symptoms due to strong and differential responses to the virus.

Suggested Citation

  • Tiago Fazolo & Karina Lima & Julia C. Fontoura & Priscila Oliveira Souza & Gabriel Hilario & Renata Zorzetto & Luiz Rodrigues Júnior & Veridiane Maria Pscheidt & Jayme Castilhos Ferreira Neto & Alisso, 2021. "Pediatric COVID-19 patients in South Brazil show abundant viral mRNA and strong specific anti-viral responses," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-27120-y
    DOI: 10.1038/s41467-021-27120-y
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    References listed on IDEAS

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    1. Angkana T. Huang & Bernardo Garcia-Carreras & Matt D. T. Hitchings & Bingyi Yang & Leah C. Katzelnick & Susan M. Rattigan & Brooke A. Borgert & Carlos A. Moreno & Benjamin D. Solomon & Luke Trimmer-Sm, 2020. "A systematic review of antibody mediated immunity to coronaviruses: kinetics, correlates of protection, and association with severity," Nature Communications, Nature, vol. 11(1), pages 1-16, December.
    2. Carolina Lucas & Patrick Wong & Jon Klein & Tiago B. R. Castro & Julio Silva & Maria Sundaram & Mallory K. Ellingson & Tianyang Mao & Ji Eun Oh & Benjamin Israelow & Takehiro Takahashi & Maria Tokuyam, 2020. "Longitudinal analyses reveal immunological misfiring in severe COVID-19," Nature, Nature, vol. 584(7821), pages 463-469, August.
    Full references (including those not matched with items on IDEAS)

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    Cited by:

    1. Julia T. Castro & Patrick Azevedo & Marcílio J. Fumagalli & Natalia S. Hojo-Souza & Natalia Salazar & Gregório G. Almeida & Livia I. Oliveira & Lídia Faustino & Lis R. Antonelli & Tomas G. Marçal & Ma, 2022. "Promotion of neutralizing antibody-independent immunity to wild-type and SARS-CoV-2 variants of concern using an RBD-Nucleocapsid fusion protein," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

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